Age-related variations in the methylome associated with gene expression in human monocytes and T cells

Lindsay M. Reynolds, Jackson R. Taylor, Jingzhong Ding, Kurt Lohman, Craig Johnson, David Siscovick, Gregory Burke, Wendy Post, Steven Shea, David R. Jacobs, Hendrik Stunnenberg, Stephen B. Kritchevsky, Ina Hoeschele, Charles E. McCall, David M. Herrington, Russell P. Tracy and Yongmei Liu ()
Additional contact information
Lindsay M. Reynolds: Wake Forest School of Medicine
Jackson R. Taylor: Wake Forest School of Medicine
Jingzhong Ding: Wake Forest School of Medicine
Kurt Lohman: Wake Forest School of Medicine
Craig Johnson: University of Washington
David Siscovick: University of Washington
Gregory Burke: Wake Forest School of Medicine
Wendy Post: Johns Hopkins University
Steven Shea: Columbia University Medical Center
David R. Jacobs: School of Public Health, University of Minnesota
Hendrik Stunnenberg: Nijmegen Centre for Molecular Life Sciences (NCMLS)
Stephen B. Kritchevsky: Wake Forest School of Medicine
Ina Hoeschele: Virginia Bioinformatics Institute, Virginia Tech
Charles E. McCall: J. Paul Sticht Center on Aging, Wake Forest School of Medicine
David M. Herrington: Wake Forest School of Medicine
Russell P. Tracy: University of Vermont
Yongmei Liu: Wake Forest School of Medicine

Nature Communications, 2014, vol. 5, issue 1, 1-8

Abstract: Abstract Age-related variations in DNA methylation have been reported; however, the functional relevance of these differentially methylated sites (age-dMS) are unclear. Here we report potentially functional age-dMS, defined as age- and cis-gene expression-associated methylation sites (age-eMS), identified by integrating genome-wide CpG methylation and gene expression profiles collected ex vivo from circulating T cells (227 CD4+ samples) and monocytes (1,264 CD14+ samples, age range: 55–94 years). None of the age-eMS detected in 227 T-cell samples are detectable in 1,264 monocyte samples, in contrast to the majority of age-dMS detected in T cells that replicated in monocytes. Age-eMS tend to be hypomethylated with older age, located in predicted enhancers and preferentially linked to expression of antigen processing and presentation genes. These results identify and characterize potentially functional age-related methylation in human T cells and monocytes, and provide novel insights into the role age-dMS may have in the aging process.

Date: 2014
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DOI: 10.1038/ncomms6366

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