Genomic landscape of metastatic colorectal cancer

Josien C. Haan, Mariette Labots, Christian Rausch, Miriam Koopman, Jolien Tol, Leonie J. M. Mekenkamp, Mark A. van de Wiel, Danielle Israeli, Hendrik F. van Essen, Nicole C. T. van Grieken, Quirinus J. M. Voorham, Linda J. W. Bosch, Xueping Qu, Omar Kabbarah, Henk M. W. Verheul, Iris D. Nagtegaal, Cornelis J. A. Punt, Bauke Ylstra and Gerrit A. Meijer ()
Additional contact information
Josien C. Haan: VU University Medical Center
Mariette Labots: VU University Medical Center
Christian Rausch: VU University Medical Center
Miriam Koopman: University Medical Center Utrecht
Jolien Tol: Radboud University Medical Centre
Leonie J. M. Mekenkamp: Radboud University Medical Centre
Mark A. van de Wiel: VU University Medical Center
Danielle Israeli: VU University Medical Center
Hendrik F. van Essen: VU University Medical Center
Nicole C. T. van Grieken: VU University Medical Center
Quirinus J. M. Voorham: VU University Medical Center
Linda J. W. Bosch: VU University Medical Center
Xueping Qu: Oncology Biomarker Development, Genentech, Inc.
Omar Kabbarah: Oncology Biomarker Development, Genentech, Inc.
Henk M. W. Verheul: VU University Medical Center
Iris D. Nagtegaal: Radboud University Medical Centre
Cornelis J. A. Punt: Academic Medical Center
Bauke Ylstra: VU University Medical Center
Gerrit A. Meijer: VU University Medical Center

Nature Communications, 2014, vol. 5, issue 1, 1-12

Abstract: Abstract Response to drug therapy in individual colorectal cancer (CRC) patients is associated with tumour biology. Here we describe the genomic landscape of tumour samples of a homogeneous well-annotated series of patients with metastatic CRC (mCRC) of two phase III clinical trials, CAIRO and CAIRO2. DNA copy number aberrations of 349 patients are determined. Within three treatment arms, 194 chromosomal subregions are associated with progression-free survival (PFS; uncorrected single-test P-values

Date: 2014
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DOI: 10.1038/ncomms6457

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