Real-time estimation and biofeedback of single-neuron firing rates using local field potentials

Thomas M. Hall, Kianoush Nazarpour and Andrew Jackson ()
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Thomas M. Hall: Institute of Neuroscience, Medical School, Newcastle University
Kianoush Nazarpour: Institute of Neuroscience, Medical School, Newcastle University
Andrew Jackson: Institute of Neuroscience, Medical School, Newcastle University

Nature Communications, 2014, vol. 5, issue 1, 1-12

Abstract: Abstract The long-term stability and low-frequency composition of local field potentials (LFPs) offer important advantages for robust and efficient neuroprostheses. However, cortical LFPs recorded by multi-electrode arrays are often assumed to contain only redundant information arising from the activity of large neuronal populations. Here we show that multichannel LFPs in monkey motor cortex each contain a slightly different mixture of distinctive slow potentials that accompany neuronal firing. As a result, the firing rates of individual neurons can be estimated with surprising accuracy. We implemented this method in a real-time biofeedback brain–machine interface, and found that monkeys could learn to modulate the activity of arbitrary neurons using feedback derived solely from LFPs. These findings provide a principled method for monitoring individual neurons without long-term recording of action potentials.

Date: 2014
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DOI: 10.1038/ncomms6462

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