Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation

Maureen Cetera, Guillermina R. Ramirez-San Juan, Patrick W. Oakes, Lindsay Lewellyn, Michael J. Fairchild, Guy Tanentzapf, Margaret L. Gardel and Sally Horne-Badovinac ()
Additional contact information
Maureen Cetera: The University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
Guillermina R. Ramirez-San Juan: The University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
Patrick W. Oakes: Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Lindsay Lewellyn: The University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
Michael J. Fairchild: Life Sciences Centre, University of British Columbia
Guy Tanentzapf: Life Sciences Centre, University of British Columbia
Margaret L. Gardel: Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Sally Horne-Badovinac: The University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA

Nature Communications, 2014, vol. 5, issue 1, 1-12

Abstract: Abstract Tissues use numerous mechanisms to change shape during development. The Drosophila egg chamber is an organ-like structure that elongates to form an elliptical egg. During elongation the follicular epithelial cells undergo a collective migration that causes the egg chamber to rotate within its surrounding basement membrane. Rotation coincides with the formation of a ‘molecular corset’, in which actin bundles in the epithelium and fibrils in the basement membrane are all aligned perpendicular to the elongation axis. Here we show that rotation plays a critical role in building the actin-based component of the corset. Rotation begins shortly after egg chamber formation and requires lamellipodial protrusions at each follicle cell’s leading edge. During early stages, rotation is necessary for tissue-level actin bundle alignment, but it becomes dispensable after the basement membrane is polarized. This work highlights how collective cell migration can be used to build a polarized tissue organization for organ morphogenesis.

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/ncomms6511 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6511

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms6511

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().