Serotonin receptor 3A controls interneuron migration into the neocortex

Sahana Murthy, Mathieu Niquille, Nicolas Hurni, Greta Limoni, Sarah Frazer, Pascal Chameau, Johannes A. van Hooft, Tania Vitalis and Alexandre Dayer ()
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Sahana Murthy: University of Geneva Medical School
Mathieu Niquille: University of Geneva Medical School
Nicolas Hurni: University of Geneva Medical School
Greta Limoni: University of Geneva Medical School
Sarah Frazer: University of Geneva Medical School
Pascal Chameau: Swammerdam Institute for Life Sciences, Center for NeuroScience, University of Amsterdam
Johannes A. van Hooft: Swammerdam Institute for Life Sciences, Center for NeuroScience, University of Amsterdam
Tania Vitalis: CNRS-UMR 8249, Brain Plasticity Unit, ESPCI ParisTech
Alexandre Dayer: University of Geneva Medical School

Nature Communications, 2014, vol. 5, issue 1, 1-10

Abstract: Abstract Neuronal excitability has been shown to control the migration and cortical integration of reelin-expressing cortical interneurons (INs) arising from the caudal ganglionic eminence (CGE), supporting the possibility that neurotransmitters could regulate this process. Here we show that the ionotropic serotonin receptor 3A (5-HT3AR) is specifically expressed in CGE-derived migrating interneurons and upregulated while they invade the developing cortex. Functional investigations using calcium imaging, electrophysiological recordings and migration assays indicate that CGE-derived INs increase their response to 5-HT3AR activation during the late phase of cortical plate invasion. Using genetic loss-of-function approaches and in vivo grafts, we further demonstrate that the 5-HT3AR is cell autonomously required for the migration and proper positioning of reelin-expressing CGE-derived INs in the neocortex. Our findings reveal a requirement for a serotonin receptor in controlling the migration and laminar positioning of a specific subtype of cortical IN.

Date: 2014
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DOI: 10.1038/ncomms6524

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