Unique features of the m6A methylome in Arabidopsis thaliana

Guan-Zheng Luo, Alice MacQueen, Guanqun Zheng, Hongchao Duan, Louis C. Dore, Zhike Lu, Jun Liu, Kai Chen, Guifang Jia (), Joy Bergelson () and Chuan He ()
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Guan-Zheng Luo: The University of Chicago
Alice MacQueen: The University of Chicago
Guanqun Zheng: The University of Chicago
Hongchao Duan: Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University
Louis C. Dore: The University of Chicago
Zhike Lu: The University of Chicago
Jun Liu: Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University
Kai Chen: The University of Chicago
Guifang Jia: Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University
Joy Bergelson: The University of Chicago
Chuan He: The University of Chicago

Nature Communications, 2014, vol. 5, issue 1, 1-8

Abstract: Abstract Recent discoveries of reversible N6-methyladenosine (m6A) methylation on messenger RNA (mRNA) and mapping of m6A methylomes in mammals and yeast have revealed potential regulatory functions of this RNA modification. In plants, defects in m6A methyltransferase cause an embryo-lethal phenotype, suggesting a critical role of m6A in plant development. Here, we profile m6A transcriptome-wide in two accessions of Arabidopsis thaliana and reveal that m6A is a highly conserved modification of mRNA in plants. Distinct from mammals, m6A in A. thaliana is enriched not only around the stop codon and within 3′-untranslated regions, but also around the start codon. Gene ontology analysis indicates that the unique distribution pattern of m6A in A. thaliana is associated with plant-specific pathways involving the chloroplast. We also discover a positive correlation between m6A deposition and mRNA abundance, suggesting a regulatory role of m6A in plant gene expression.

Date: 2014
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DOI: 10.1038/ncomms6630

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