The role of protein clearance mechanisms in organismal ageing and age-related diseases

David Vilchez, Isabel Saez and Andrew Dillin ()
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David Vilchez: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Isabel Saez: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Andrew Dillin: The University of California, Berkeley, Li Ka Shing Center for Biomedical and Health Sciences

Nature Communications, 2014, vol. 5, issue 1, 1-13

Abstract: Proteins are subject to continuous and complex quality-control mechanisms, which ensure integrity of the proteome. Vilchez et al.review how a demise in these processes, collectively referred to as proteostasis, is linked to organismal ageing and the development of age-associated diseases.

Date: 2014
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DOI: 10.1038/ncomms6659

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