Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour

Subhashis Banerjee, Yongjun Wang, Laura A. Solt, Kristine Griffett, Melissa Kazantzis, Ariadna Amador, Bahaa M. El-Gendy, Salvador Huitron-Resendiz, Amanda J. Roberts, Youseung Shin, Theodore M. Kamenecka and Thomas P. Burris ()
Additional contact information
Subhashis Banerjee: The Scripps Research Institute
Yongjun Wang: Saint Louis University School of Medicine
Laura A. Solt: The Scripps Research Institute
Kristine Griffett: Saint Louis University School of Medicine
Melissa Kazantzis: The Scripps Research Institute
Ariadna Amador: The Scripps Research Institute
Bahaa M. El-Gendy: The Scripps Research Institute
Salvador Huitron-Resendiz: The Scripps Research Institute
Amanda J. Roberts: The Scripps Research Institute
Youseung Shin: The Scripps Research Institute
Theodore M. Kamenecka: The Scripps Research Institute
Thomas P. Burris: Saint Louis University School of Medicine

Nature Communications, 2014, vol. 5, issue 1, 1-13

Abstract: Abstract Synthetic drug-like molecules that directly modulate the activity of key clock proteins offer the potential to directly modulate the endogenous circadian rhythm and treat diseases associated with clock dysfunction. Here we demonstrate that synthetic ligands targeting a key component of the mammalian clock, the nuclear receptors REV-ERBα and β, regulate sleep architecture and emotional behaviour in mice. REV-ERB agonists induce wakefulness and reduce REM and slow-wave sleep. Interestingly, REV-ERB agonists also reduce anxiety-like behaviour. These data are consistent with increased anxiety-like behaviour of REV-ERBβ-null mice, in which REV-ERB agonists have no effect. These results indicate that pharmacological targeting of REV-ERB may lead to the development of novel therapeutics to treat sleep disorders and anxiety.

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/ncomms6759 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6759

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms6759

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().