Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation

Qingtian Li, Jia Zou, Mingjun Wang, Xilai Ding, Iouri Chepelev, Xikun Zhou, Wei Zhao, Gang Wei, Jun Cui, Keji Zhao, Helen Y. Wang and Rong-Fu Wang ()
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Qingtian Li: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Jia Zou: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Mingjun Wang: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Xilai Ding: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Iouri Chepelev: Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center
Xikun Zhou: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Wei Zhao: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Gang Wei: CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences
Jun Cui: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Keji Zhao: Systems Biology Center, National Heart, Lung, and Blood Institute, NIH
Helen Y. Wang: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Rong-Fu Wang: Center for Inflammation and Epigenetics, Houston Methodist Research Institute

Nature Communications, 2014, vol. 5, issue 1, 1-15

Abstract: Abstract Epigenetic factors have been implicated in the regulation of CD4+ T-cell differentiation. Jmjd3 plays a role in many biological processes, but its in vivo function in T-cell differentiation remains unknown. Here we report that Jmjd3 ablation promotes CD4+ T-cell differentiation into Th2 and Th17 cells in the small intestine and colon, and inhibits T-cell differentiation into Th1 cells under different cytokine-polarizing conditions and in a Th1-dependent colitis model. Jmjd3 deficiency also restrains the plasticity of the conversion of Th2, Th17 or Treg cells to Th1 cells. The skewing of T-cell differentiation is concomitant with changes in the expression of key transcription factors and cytokines. H3K27me3 and H3K4me3 levels in Jmjd3-deficient cells are correlated with altered gene expression through interactions with specific transcription factors. Our results identify Jmjd3 as an epigenetic factor in T-cell differentiation via changes in histone methylation and target gene expression.

Date: 2014
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DOI: 10.1038/ncomms6780

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