Evidence for zoonotic potential of ovine scrapie prions

Hervé Cassard, Juan-Maria Torres, Caroline Lacroux, Jean-Yves Douet, Sylvie L. Benestad, Frédéric Lantier, Séverine Lugan, Isabelle Lantier, Pierrette Costes, Naima Aron, Fabienne Reine, Laetitia Herzog, Juan-Carlos Espinosa, Vincent Beringue and Olivier Andréoletti ()
Additional contact information
Hervé Cassard: UMR INRA ENVT 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse
Juan-Maria Torres: CISA- INIA
Caroline Lacroux: UMR INRA ENVT 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse
Jean-Yves Douet: UMR INRA ENVT 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse
Sylvie L. Benestad: Norwegian Veterinary Institute
Frédéric Lantier: INRA ISP, Centre INRA de Tours
Séverine Lugan: UMR INRA ENVT 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse
Isabelle Lantier: INRA ISP, Centre INRA de Tours
Pierrette Costes: UMR INRA ENVT 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse
Naima Aron: UMR INRA ENVT 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse
Fabienne Reine: UR892 Virologie et Immunologie Moléculaires Centre de Recherche de Jouy-en-Josas
Laetitia Herzog: UR892 Virologie et Immunologie Moléculaires Centre de Recherche de Jouy-en-Josas
Juan-Carlos Espinosa: CISA- INIA
Vincent Beringue: UR892 Virologie et Immunologie Moléculaires Centre de Recherche de Jouy-en-Josas
Olivier Andréoletti: UMR INRA ENVT 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse

Nature Communications, 2014, vol. 5, issue 1, 1-9

Abstract: Abstract Although Bovine Spongiform Encephalopathy (BSE) is the cause of variant Creutzfeldt Jakob disease (vCJD) in humans, the zoonotic potential of scrapie prions remains unknown. Mice genetically engineered to overexpress the human prion protein (tgHu) have emerged as highly relevant models for gauging the capacity of prions to transmit to humans. These models can propagate human prions without any apparent transmission barrier and have been used used to confirm the zoonotic ability of BSE. Here we show that a panel of sheep scrapie prions transmit to several tgHu mice models with an efficiency comparable to that of cattle BSE. The serial transmission of different scrapie isolates in these mice led to the propagation of prions that are phenotypically identical to those causing sporadic CJD (sCJD) in humans. These results demonstrate that scrapie prions have a zoonotic potential and raise new questions about the possible link between animal and human prions.

Date: 2014
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DOI: 10.1038/ncomms6821

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