A tetrahelical DNA fold adopted by tandem repeats of alternating GGG and GCG tracts

Vojč Kocman and Janez Plavec ()
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Vojč Kocman: Slovenian NMR Centre, National Institute of Chemistry
Janez Plavec: Slovenian NMR Centre, National Institute of Chemistry

Nature Communications, 2014, vol. 5, issue 1, 1-11

Abstract: Abstract DNA can form diverse higher-order structures, whose details are greatly dependent on nucleotide sequence. G-rich sequences containing four or more repeats of three guanines are expected to form G-quadruplexes. Here we show that DNA sequences with GGGAGCG repeats found in the regulatory region of the PLEKHG3 gene are capable of forming tetrahelical DNA structures that are distinct from G-quadruplexes. The d(GGGAGCGAGGGAGCG) sequence, VK1, forms a dimer. Two VK1 sequences connected by an adenine residue, VK2, fold into a monomer, which shares identical structural characteristics with the VK1 fold. Their four-stranded architectures are stabilized by four G-C, four G-A and six G-G base pairs. No G-quartets or Hoogsteen-type hydrogen-bonded guanine residues are present and the overall topology is conserved in the presence of Li+, Na+, K+ and NH4+ ions. Unique structural features include two edgewise loops on each side of the structure stabilized by three G-G base pairs in N1-carbonyl symmetric geometry.

Date: 2014
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DOI: 10.1038/ncomms6831

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