Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle

Mathew D. Littlejohn (), Kristen M. Henty, Kathryn Tiplady, Thomas Johnson, Chad Harland, Thomas Lopdell, Richard G. Sherlock, Wanbo Li, Steven D. Lukefahr, Bruce C. Shanks, Dorian J. Garrick, Russell G. Snell, Richard J. Spelman and Stephen R. Davis ()
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Mathew D. Littlejohn: Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads
Kristen M. Henty: School of Biological Sciences, University of Auckland
Kathryn Tiplady: Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads
Thomas Johnson: Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads
Chad Harland: Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads
Thomas Lopdell: Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads
Richard G. Sherlock: Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads
Wanbo Li: Unit of Animal Genomics, GIGA-R, Faculty of Veterinary Medicine, University of Liège (B34)
Steven D. Lukefahr: Rangeland and Wildlife Sciences, Texas A&M University-Kingsville, MSC 228, Kingsville, Texas 78363-8202, USA
Bruce C. Shanks: Lincoln University
Dorian J. Garrick: Iowa State University
Russell G. Snell: School of Biological Sciences, University of Auckland
Richard J. Spelman: Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads
Stephen R. Davis: Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads

Nature Communications, 2014, vol. 5, issue 1, 1-8

Abstract: Abstract Lactation, hair development and homeothermy are characteristic evolutionary features that define mammals from other vertebrate species. Here we describe the discovery of two autosomal dominant mutations with antagonistic, pleiotropic effects on all three of these biological processes, mediated through the prolactin signalling pathway. Most conspicuously, mutations in prolactin (PRL) and its receptor (PRLR) have an impact on thermoregulation and hair morphology phenotypes, giving prominence to this pathway outside of its classical roles in lactation.

Date: 2014
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DOI: 10.1038/ncomms6861

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