Transcriptome meta-analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes

Saravana M. Dhanasekaran, O Alejandro Balbin, Guoan Chen, Ernest Nadal, Shanker Kalyana-Sundaram, Jincheng Pan, Brendan Veeneman, Xuhong Cao, Rohit Malik, Pankaj Vats, Rui Wang, Stephanie Huang, Jinjie Zhong, Xiaojun Jing, Matthew Iyer, Yi-Mi Wu, Paul W. Harms, Jules Lin, Rishindra Reddy, Christine Brennan, Nallasivam Palanisamy, Andrew C. Chang, Anna Truini, Mauro Truini, Dan R. Robinson, David G. Beer () and Arul M. Chinnaiyan ()
Additional contact information
Saravana M. Dhanasekaran: Michigan Center for Translational Pathology, University of Michigan Medical School
O Alejandro Balbin: Michigan Center for Translational Pathology, University of Michigan Medical School
Guoan Chen: Thoracic Surgery, University of Michigan Medical School
Ernest Nadal: Thoracic Surgery, University of Michigan Medical School
Shanker Kalyana-Sundaram: Michigan Center for Translational Pathology, University of Michigan Medical School
Jincheng Pan: Michigan Center for Translational Pathology, University of Michigan Medical School
Brendan Veeneman: Michigan Center for Translational Pathology, University of Michigan Medical School
Xuhong Cao: Michigan Center for Translational Pathology, University of Michigan Medical School
Rohit Malik: Michigan Center for Translational Pathology, University of Michigan Medical School
Pankaj Vats: Michigan Center for Translational Pathology, University of Michigan Medical School
Rui Wang: Michigan Center for Translational Pathology, University of Michigan Medical School
Stephanie Huang: Michigan Center for Translational Pathology, University of Michigan Medical School
Jinjie Zhong: Xinjiang Medical University
Xiaojun Jing: Michigan Center for Translational Pathology, University of Michigan Medical School
Matthew Iyer: Michigan Center for Translational Pathology, University of Michigan Medical School
Yi-Mi Wu: Michigan Center for Translational Pathology, University of Michigan Medical School
Paul W. Harms: Michigan Center for Translational Pathology, University of Michigan Medical School
Jules Lin: Thoracic Surgery, University of Michigan Medical School
Rishindra Reddy: Thoracic Surgery, University of Michigan Medical School
Christine Brennan: Michigan Center for Translational Pathology, University of Michigan Medical School
Nallasivam Palanisamy: Michigan Center for Translational Pathology, University of Michigan Medical School
Andrew C. Chang: Thoracic Surgery, University of Michigan Medical School
Anna Truini: Lung Cancer Unit, IRCCS AOU San Martino-IST National Institute for Cancer Research
Mauro Truini: IRCCS AOU San Martino-IST National Institute for Cancer Research
Dan R. Robinson: Michigan Center for Translational Pathology, University of Michigan Medical School
David G. Beer: Thoracic Surgery, University of Michigan Medical School
Arul M. Chinnaiyan: Michigan Center for Translational Pathology, University of Michigan Medical School

Nature Communications, 2014, vol. 5, issue 1, 1-12

Abstract: Abstract Lung cancer is emerging as a paradigm for disease molecular subtyping, facilitating targeted therapy based on driving somatic alterations. Here we perform transcriptome analysis of 153 samples representing lung adenocarcinomas, squamous cell carcinomas, large cell lung cancer, adenoid cystic carcinomas and cell lines. By integrating our data with The Cancer Genome Atlas and published sources, we analyse 753 lung cancer samples for gene fusions and other transcriptomic alterations. We show that higher numbers of gene fusions is an independent prognostic factor for poor survival in lung cancer. Our analysis confirms the recently reported CD74-NRG1 fusion and suggests that NRG1, NF1 and Hippo pathway fusions may play important roles in tumours without known driver mutations. In addition, we observe exon-skipping events in c-MET, which are attributable to splice site mutations. These classes of genetic aberrations may play a significant role in the genesis of lung cancers lacking known driver mutations.

Date: 2014
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms6893 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6893

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms6893

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().