An endoscope with integrated transparent bioelectronics and theranostic nanoparticles for colon cancer treatment

Hyunjae Lee, Youngsik Lee, Changyeong Song, Hye Rim Cho, Roozbeh Ghaffari, Tae Kyu Choi, Kyung Hoon Kim, Young Bum Lee, Daishun Ling, Hyuk Lee, Su Jong Yu, Seung Hong Choi (), Taeghwan Hyeon () and Dae-Hyeong Kim ()
Additional contact information
Hyunjae Lee: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Youngsik Lee: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Changyeong Song: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Hye Rim Cho: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Roozbeh Ghaffari: MC10 Inc.
Tae Kyu Choi: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Kyung Hoon Kim: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Young Bum Lee: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Daishun Ling: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Hyuk Lee: Samsung Medical Center, Sungkyunkwan University School of Medicine
Su Jong Yu: Seoul National University College of Medicine
Seung Hong Choi: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Taeghwan Hyeon: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Dae-Hyeong Kim: Center for Nanoparticle Research, Institute for Basic Science (IBS)

Nature Communications, 2015, vol. 6, issue 1, 1-10

Abstract: Abstract The gastrointestinal tract is a challenging anatomical target for diagnostic and therapeutic procedures for bleeding, polyps and cancerous growths. Advanced endoscopes that combine imaging and therapies within the gastrointestinal tract provide an advantage over stand-alone diagnostic or therapeutic devices. However, current multimodal endoscopes lack the spatial resolution necessary to detect and treat small cancers and other abnormalities. Here we present a multifunctional endoscope-based interventional system that integrates transparent bioelectronics with theranostic nanoparticles, which are photoactivated within highly localized space near tumours or benign growths. These advanced electronics and nanoparticles collectively enable optical fluorescence-based mapping, electrical impedance and pH sensing, contact/temperature monitoring, radio frequency ablation and localized photo/chemotherapy, as the basis of a closed-loop solution for colon cancer treatment. In vitro, ex vivo and in vivo experiments highlight the utility of this technology for accurate detection, delineation and rapid targeted therapy of colon cancer or precancerous lesions.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms10059 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms10059

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms10059

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().