A biomimetic hybrid nanoplatform for encapsulation and precisely controlled delivery of theranostic agents

Hai Wang, Pranay Agarwal, Shuting Zhao, Jianhua Yu, Xiongbin Lu and Xiaoming He ()
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Hai Wang: The Ohio State University
Pranay Agarwal: The Ohio State University
Shuting Zhao: The Ohio State University
Jianhua Yu: Comprehensive Cancer Center, The Ohio State University
Xiongbin Lu: University of Texas MD Anderson Cancer Center
Xiaoming He: The Ohio State University

Nature Communications, 2015, vol. 6, issue 1, 1-13

Abstract: Abstract Nanoparticles have demonstrated great potential for enhancing drug delivery. However, the low drug encapsulation efficiency at high drug-to-nanoparticle feeding ratios and minimal drug loading content in nanoparticle at any feeding ratios are major hurdles to their widespread applications. Here we report a robust eukaryotic cell-like hybrid nanoplatform (EukaCell) for encapsulation of theranostic agents (doxorubicin and indocyanine green). The EukaCell consists of a phospholipid membrane, a cytoskeleton-like mesoporous silica matrix and a nucleus-like fullerene core. At high drug-to-nanoparticle feeding ratios (for example, 1:0.5), the encapsulation efficiency and loading content can be improved by 58 and 21 times, respectively, compared with conventional silica nanoparticles. Moreover, release of the encapsulated drug can be precisely controlled via dosing near infrared laser irradiation. Ultimately, the ultra-high (up to ∼87%) loading content renders augmented anticancer capacity both in vitro and in vivo. Our EukaCell is valuable for drug delivery to fight against cancer and potentially other diseases.

Date: 2015
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DOI: 10.1038/ncomms10081

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