Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas

Kui Wu, Xin Zhang, Fuqiang Li, Dakai Xiao, Yong Hou, Shida Zhu, Dongbing Liu, Xiaofei Ye, Mingzhi Ye, Jie Yang, Libin Shao, Hui Pan, Na Lu, Yuan Yu, Liping Liu, Jin Li, Liyan Huang, Hailing Tang, Qiuhua Deng, Yue Zheng, Lihua Peng, Geng Liu, Xia Gu, Ping He, Yingying Gu, Weixuan Lin, Huiming He, Guoyun Xie, Han Liang, Na An, Hui Wang, Manuel Teixeira, Joana Vieira, Wenhua Liang, Xin Zhao, Zhiyu Peng, Feng Mu, Xiuqing Zhang, Xun Xu, Huanming Yang, Karsten Kristiansen, Jian Wang, Nanshan Zhong, Jun Wang (), Qiang Pan-Hammarström () and Jianxing He ()
Additional contact information
Kui Wu: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Xin Zhang: The First Affiliated Hospital of Guangzhou Medical University
Fuqiang Li: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Dakai Xiao: The First Affiliated Hospital of Guangzhou Medical University
Yong Hou: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Shida Zhu: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Dongbing Liu: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Xiaofei Ye: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Mingzhi Ye: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Jie Yang: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Libin Shao: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Hui Pan: The First Affiliated Hospital of Guangzhou Medical University
Na Lu: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Yuan Yu: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Liping Liu: The First Affiliated Hospital of Guangzhou Medical University
Jin Li: The First Affiliated Hospital of Guangzhou Medical University
Liyan Huang: The First Affiliated Hospital of Guangzhou Medical University
Hailing Tang: The First Affiliated Hospital of Guangzhou Medical University
Qiuhua Deng: The First Affiliated Hospital of Guangzhou Medical University
Yue Zheng: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Lihua Peng: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Geng Liu: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Xia Gu: The First Affiliated Hospital of Guangzhou Medical University
Ping He: The First Affiliated Hospital of Guangzhou Medical University
Yingying Gu: Guangzhou Institute of Respiratory Disease & State Key Laboratory of Respiratory Disease
Weixuan Lin: Research Center for Translational Medicine, The First Affiliated Hospital of Guangzhou Medical University
Huiming He: Research Center for Translational Medicine, The First Affiliated Hospital of Guangzhou Medical University
Guoyun Xie: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Han Liang: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Na An: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Hui Wang: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Manuel Teixeira: Portuguese Oncology Institute
Joana Vieira: Portuguese Oncology Institute
Wenhua Liang: The First Affiliated Hospital of Guangzhou Medical University
Xin Zhao: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Zhiyu Peng: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Feng Mu: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Xiuqing Zhang: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Xun Xu: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Huanming Yang: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Karsten Kristiansen: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Jian Wang: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Nanshan Zhong: Guangzhou Institute of Respiratory Disease & State Key Laboratory of Respiratory Disease
Jun Wang: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Qiang Pan-Hammarström: BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China
Jianxing He: The First Affiliated Hospital of Guangzhou Medical University

Nature Communications, 2015, vol. 6, issue 1, 1-13

Abstract: Abstract The landscape of genetic alterations in lung adenocarcinoma derived from Asian patients is largely uncharacterized. Here we present an integrated genomic and transcriptomic analysis of 335 primary lung adenocarcinomas and 35 corresponding lymph node metastases from Chinese patients. Altogether 13 significantly mutated genes are identified, including the most commonly mutated gene TP53 and novel mutation targets such as RHPN2, GLI3 and MRC2. TP53 mutations are furthermore significantly enriched in tumours from patients harbouring metastases. Genes regulating cytoskeleton remodelling processes are also frequently altered, especially in metastatic samples, of which the high expression level of IQGAP3 is identified as a marker for poor prognosis. Our study represents the first large-scale sequencing effort on lung adenocarcinoma in Asian patients and provides a comprehensive mutational landscape for both primary and metastatic tumours. This may thus form a basis for personalized medical care and shed light on the molecular pathogenesis of metastatic lung adenocarcinoma.

Date: 2015
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DOI: 10.1038/ncomms10131

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