Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese

Clara S. Tang, He Zhang, Chloe Y. Y. Cheung, Ming Xu, Jenny C. Y. Ho, Wei Zhou, Stacey S. Cherny, Yan Zhang, Oddgeir Holmen, Ka-Wing Au, Haiyi Yu, Lin Xu, Jia Jia, Robert M. Porsch, Lijie Sun, Weixian Xu, Huiping Zheng, Lai-Yung Wong, Yiming Mu, Jingtao Dou, Carol H. Y. Fong, Shuyu Wang, Xueyu Hong, Liguang Dong, Yanhua Liao, Jiansong Wang, Levina S. M. Lam, Xi Su, Hua Yan, Min-Lee Yang, Jin Chen, Chung-Wah Siu, Gaoqiang Xie, Yu-Cho Woo, Yangfeng Wu, Kathryn C. B. Tan, Kristian Hveem, Bernard M. Y. Cheung, Sebastian Zöllner, Aimin Xu, Y Eugene Chen, Chao Qiang Jiang, Youyi Zhang, Tai-Hing Lam, Santhi K. Ganesh, Yong Huo, Pak C. Sham, Karen S. L. Lam, Cristen J. Willer (), Hung-Fat Tse () and Wei Gao
Additional contact information
Clara S. Tang: the University of Hong Kong
He Zhang: University of Michigan
Chloe Y. Y. Cheung: the University of Hong Kong
Ming Xu: Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education
Jenny C. Y. Ho: the University of Hong Kong
Wei Zhou: University of Michigan
Stacey S. Cherny: the University of Hong Kong
Yan Zhang: Peking University First Hospital
Oddgeir Holmen: HUNT Research Centre, Norwegian University of Science and Technology
Ka-Wing Au: the University of Hong Kong
Haiyi Yu: Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education
Lin Xu: School of Public Health, the University of Hong Kong
Jia Jia: Peking University First Hospital
Robert M. Porsch: the University of Hong Kong
Lijie Sun: Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education
Weixian Xu: Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education
Huiping Zheng: Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education
Lai-Yung Wong: the University of Hong Kong
Yiming Mu: Chinese People's Liberation Army General Hospital
Jingtao Dou: Chinese People's Liberation Army General Hospital
Carol H. Y. Fong: the University of Hong Kong
Shuyu Wang: Beijing Hypertension League Institute
Xueyu Hong: the University of Hong Kong
Liguang Dong: Peking University Shougang Hospital
Yanhua Liao: Peking University Shougang Hospital
Jiansong Wang: Peking University Shougang Hospital
Levina S. M. Lam: Centre for Genomic Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Xi Su: Wuhan Asia Heart Hospital
Hua Yan: Wuhan Asia Heart Hospital
Min-Lee Yang: University of Michigan
Jin Chen: University of Michigan
Chung-Wah Siu: the University of Hong Kong
Gaoqiang Xie: Peking University Clinical Research Institute
Yu-Cho Woo: the University of Hong Kong
Yangfeng Wu: Peking University Clinical Research Institute, Peking University School of Public Health
Kathryn C. B. Tan: the University of Hong Kong
Kristian Hveem: HUNT Research Centre, Norwegian University of Science and Technology
Bernard M. Y. Cheung: the University of Hong Kong
Sebastian Zöllner: Center for Statistical Genetics, University of Michigan School of Public Health
Aimin Xu: the University of Hong Kong
Y Eugene Chen: University of Michigan
Chao Qiang Jiang: Guangzhou No.12 Hospital
Youyi Zhang: Institute of Vascular Medicine, Peking University Third Hospital, Beijing Key Laboratory of Cardiovascular Receptors Research
Tai-Hing Lam: School of Public Health, the University of Hong Kong
Santhi K. Ganesh: University of Michigan
Yong Huo: Peking University First Hospital
Pak C. Sham: the University of Hong Kong
Karen S. L. Lam: the University of Hong Kong
Cristen J. Willer: University of Michigan
Hung-Fat Tse: the University of Hong Kong
Wei Gao: Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health

Nature Communications, 2015, vol. 6, issue 1, 1-9

Abstract: Abstract Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional loci influencing lipid levels. Single-variant association analysis on 65,671 single nucleotide polymorphisms reveals 19 loci associated with lipids at exome-wide significance (P

Date: 2015
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DOI: 10.1038/ncomms10206

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