A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Joseph Vijai (), Zhaoming Wang, Sonja I. Berndt, Christine F. Skibola, Susan L. Slager, Silvia de Sanjose, Mads Melbye, Bengt Glimelius, Paige M. Bracci, Lucia Conde, Brenda M. Birmann, Sophia S. Wang, Angela R. Brooks-Wilson, Qing Lan, Paul I. W. de Bakker, Roel C. H. Vermeulen, Carol Portlock, Stephen M. Ansell, Brian K. Link, Jacques Riby, Kari E. North, Jian Gu, Henrik Hjalgrim, Wendy Cozen, Nikolaus Becker, Lauren R. Teras, John J. Spinelli, Jenny Turner, Yawei Zhang, Mark P. Purdue, Graham G. Giles, Rachel S. Kelly, Anne Zeleniuch-Jacquotte, Maria Grazia Ennas, Alain Monnereau, Kimberly A. Bertrand, Demetrius Albanes, Tracy Lightfoot, Meredith Yeager, Charles C. Chung, Laurie Burdett, Amy Hutchinson, Charles Lawrence, Rebecca Montalvan, Liming Liang, Jinyan Huang, Baoshan Ma, Danylo J. Villano, Ann Maria, Marina Corines, Tinu Thomas, Anne J. Novak, Ahmet Dogan, Mark Liebow, Carrie A. Thompson, Thomas E. Witzig, Thomas M. Habermann, George J. Weiner, Martyn T. Smith, Elizabeth A. Holly, Rebecca D. Jackson, Lesley F. Tinker, Yuanqing Ye, Hans-Olov Adami, Karin E. Smedby, Anneclaire J. De Roos, Patricia Hartge, Lindsay M. Morton, Richard K. Severson, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Lenka Foretova, Marc Maynadie, James McKay, Anthony Staines, W. Ryan Diver, Claire M. Vajdic, Bruce K. Armstrong, Anne Kricker, Tongzhang Zheng, Theodore R. Holford, Gianluca Severi, Paolo Vineis, Giovanni M. Ferri, Rosalia Ricco, Lucia Miligi, Jacqueline Clavel, Edward Giovannucci, Peter Kraft, Jarmo Virtamo, Alex Smith, Eleanor Kane, Eve Roman, Brian C. H. Chiu, Joseph F. Fraumeni, Xifeng Wu, James R. Cerhan, Kenneth Offit, Stephen J. Chanock, Nathaniel Rothman and Alexandra Nieters
Additional contact information
Joseph Vijai: Memorial Sloan-Kettering Cancer Center
Zhaoming Wang: Cancer Genomics Research Laboratory, National Cancer Institute
Sonja I. Berndt: National Cancer Institute
Christine F. Skibola: School of Public Health and Comprehensive Cancer Center
Susan L. Slager: Mayo Clinic
Silvia de Sanjose: Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d’Oncologia, IDIBELL
Mads Melbye: Statens Serum Institut
Bengt Glimelius: Karolinska Institutet, Karolinska University Hospital Solna
Paige M. Bracci: University of California San Francisco
Lucia Conde: School of Public Health and Comprehensive Cancer Center
Brenda M. Birmann: Brigham and Women’s Hospital and Harvard Medical School
Sophia S. Wang: City of Hope Beckman Research Institute
Angela R. Brooks-Wilson: Genome Sciences Centre, BC Cancer Agency
Qing Lan: National Cancer Institute
Paul I. W. de Bakker: Center for Molecular Medicine, University Medical Center Utrecht
Roel C. H. Vermeulen: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht
Carol Portlock: Memorial Sloan-Kettering Cancer Center
Stephen M. Ansell: Mayo Clinic
Brian K. Link: Carver College of Medicine, The University of Iowa
Jacques Riby: School of Public Health and Comprehensive Cancer Center
Kari E. North: University of North Carolina at Chapel Hill
Jian Gu: M.D. Anderson Cancer Center
Henrik Hjalgrim: Statens Serum Institut
Wendy Cozen: USC Keck School of Medicine, University of Southern California
Nikolaus Becker: German Cancer Research Center (DKFZ)
Lauren R. Teras: Epidemiology Research Program, American Cancer Society
John J. Spinelli: Cancer Control Research, BC Cancer Agency
Jenny Turner: Pathology, Australian School of Advanced Medicine, Macquarie University
Yawei Zhang: Yale School of Public Health
Mark P. Purdue: National Cancer Institute
Graham G. Giles: Cancer Epidemiology Centre, Cancer Council Victoria
Rachel S. Kelly: MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
Anne Zeleniuch-Jacquotte: New York University School of Medicine
Maria Grazia Ennas: University of Cagliari
Alain Monnereau: Environmental Epidemiology of Cancer Group, Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018
Kimberly A. Bertrand: Brigham and Women’s Hospital and Harvard Medical School
Demetrius Albanes: National Cancer Institute
Tracy Lightfoot: University of York
Meredith Yeager: Cancer Genomics Research Laboratory, National Cancer Institute
Charles C. Chung: National Cancer Institute
Laurie Burdett: Cancer Genomics Research Laboratory, National Cancer Institute
Amy Hutchinson: Cancer Genomics Research Laboratory, National Cancer Institute
Charles Lawrence: Health Studies Sector, Westat
Rebecca Montalvan: Health Studies Sector, Westat
Liming Liang: Harvard School of Public Health
Jinyan Huang: Harvard School of Public Health
Baoshan Ma: Harvard School of Public Health
Danylo J. Villano: Memorial Sloan-Kettering Cancer Center
Ann Maria: Memorial Sloan-Kettering Cancer Center
Marina Corines: Memorial Sloan-Kettering Cancer Center
Tinu Thomas: Memorial Sloan-Kettering Cancer Center
Anne J. Novak: Mayo Clinic
Ahmet Dogan: Memorial Sloan-Kettering Cancer Center
Mark Liebow: Mayo Clinic
Carrie A. Thompson: Mayo Clinic
Thomas E. Witzig: Mayo Clinic
Thomas M. Habermann: Mayo Clinic
George J. Weiner: Carver College of Medicine, The University of Iowa
Martyn T. Smith: University of California Berkeley School of Public Health
Elizabeth A. Holly: University of California San Francisco
Rebecca D. Jackson: Diabetes and Metabolism, The Ohio State University
Lesley F. Tinker: Fred Hutchinson Cancer Research Center
Yuanqing Ye: M.D. Anderson Cancer Center
Hans-Olov Adami: Harvard School of Public Health
Karin E. Smedby: Karolinska Institutet
Anneclaire J. De Roos: Fred Hutchinson Cancer Research Center
Patricia Hartge: National Cancer Institute
Lindsay M. Morton: National Cancer Institute
Richard K. Severson: Wayne State University
Yolanda Benavente: Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d’Oncologia, IDIBELL
Paolo Boffetta: The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Paul Brennan: Group of Genetic Epidemiology, Section of Genetics, International Agency for Research on Cancer
Lenka Foretova: Masaryk Memorial Cancer Institute and MF MU
Marc Maynadie: EA 4184, Registre des Hémopathies Malignes de Côte d’Or, University of Burgundy and Dijon University Hospital
James McKay: Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer
Anthony Staines: School of Nursing and Human Sciences, Dublin City University
W. Ryan Diver: Epidemiology Research Program, American Cancer Society
Claire M. Vajdic: Prince of Wales Clinical School, University of New South Wales
Bruce K. Armstrong: Sydney School of Public Health, The University of Sydney
Anne Kricker: Sydney School of Public Health, The University of Sydney
Tongzhang Zheng: Yale School of Public Health
Theodore R. Holford: Yale School of Public Health
Gianluca Severi: Cancer Epidemiology Centre, Cancer Council Victoria
Paolo Vineis: MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
Giovanni M. Ferri: University of Bari
Rosalia Ricco: University of Bari
Lucia Miligi: Environmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO)
Jacqueline Clavel: Environmental Epidemiology of Cancer Group, Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018
Edward Giovannucci: Brigham and Women’s Hospital and Harvard Medical School
Peter Kraft: Harvard School of Public Health
Jarmo Virtamo: National Institute for Health and Welfare
Alex Smith: University of York
Eleanor Kane: University of York
Eve Roman: University of York
Brian C. H. Chiu: University of Chicago
Joseph F. Fraumeni: National Cancer Institute
Xifeng Wu: M.D. Anderson Cancer Center
James R. Cerhan: Mayo Clinic
Kenneth Offit: Memorial Sloan-Kettering Cancer Center
Stephen J. Chanock: National Cancer Institute
Nathaniel Rothman: National Cancer Institute
Alexandra Nieters: Center For Chronic Immunodeficiency, University Medical Center Freiburg

Nature Communications, 2015, vol. 6, issue 1, 1-7

Abstract: Abstract Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10−15) and HLA-B (rs2922994, P=2.43 × 10−9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

Date: 2015
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DOI: 10.1038/ncomms6751

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