ParaHydrogen Induced Polarization of 13C carboxylate resonance in acetate and pyruvate

Francesca Reineri, Tommaso Boi and Silvio Aime ()
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Francesca Reineri: University of Torino
Tommaso Boi: Bracco Imaging Spa, CRB, Colleretto Giacosa
Silvio Aime: University of Torino

Nature Communications, 2015, vol. 6, issue 1, 1-6

Abstract: Abstract The advent of nuclear spins hyperpolarization techniques represents a breakthrough in the field of medical diagnoses by magnetic resonance imaging. Dynamic nuclear polarization (DNP) is the most widely used method, and hyperpolarized metabolites such as [1-13C]-pyruvate are shown to report on status of tumours. Parahydrogen-induced polarization (PHIP) is a chemistry-based technique, easier to handle and much less expensive in respect to DNP, with significantly shorter polarization times. Its main limitation is the availability of unsaturated precursors for the target substrates; for instance, acetate and pyruvate cannot be obtained by direct incorporation of the parahydrogen molecule. Herein we report a method that allows us to achieve hyperpolarization in this kind of molecule by means of a tailored precursor containing a hydrogenable functionality that, after polarization transfer to the target 13C moiety, is cleaved to obtain the metabolite of interest. The reported procedure can be extended to a number of other biologically relevant substrates.

Date: 2015
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DOI: 10.1038/ncomms6858

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