CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes

Emma C. Mackley, Stephanie Houston, Clare L. Marriott, Emily E. Halford, Beth Lucas, Vuk Cerovic, Kara J. Filbey, Rick M. Maizels, Matthew R. Hepworth, Gregory F. Sonnenberg, Simon Milling and David R. Withers ()
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Emma C. Mackley: MRC Centre for Immune Regulation, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham
Stephanie Houston: Institute of Infection, Immunity and Inflammation, University of Glasgow
Clare L. Marriott: MRC Centre for Immune Regulation, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham
Emily E. Halford: MRC Centre for Immune Regulation, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham
Beth Lucas: MRC Centre for Immune Regulation, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham
Vuk Cerovic: Institute of Infection, Immunity and Inflammation, University of Glasgow
Kara J. Filbey: Institute of Immunology and Infection Research, University of Edinburgh
Rick M. Maizels: Institute of Immunology and Infection Research, University of Edinburgh
Matthew R. Hepworth: Division of Gastroenterology, Joan and Sanford I. Weill Department of Medicine
Gregory F. Sonnenberg: Division of Gastroenterology, Joan and Sanford I. Weill Department of Medicine
Simon Milling: Institute of Infection, Immunity and Inflammation, University of Glasgow
David R. Withers: MRC Centre for Immune Regulation, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham

Nature Communications, 2015, vol. 6, issue 1, 1-13

Abstract: Abstract Presentation of peptide:MHCII by RORγ-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular areas of mucosal draining lymph nodes, forming a distinct microenvironment not observed in peripheral lymph nodes. By photoconverting intestinal cells in Kaede mice we reveal constitutive trafficking of ILCs from the intestine to the draining mesenteric lymph nodes, which specifically for the LTi-like ILC3s was CCR7-dependent. Thus, ILC populations traffic to draining lymph nodes using different mechanisms.

Date: 2015
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DOI: 10.1038/ncomms6862

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