Revisiting the role of histo-blood group antigens in rotavirus host-cell invasion

Raphael Böhm, Fiona E. Fleming, Andrea Maggioni, Vi T. Dang, Gavan Holloway, Barbara S. Coulson, Mark von Itzstein () and Thomas Haselhorst ()
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Raphael Böhm: Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia
Fiona E. Fleming: The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
Andrea Maggioni: Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia
Vi T. Dang: The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
Gavan Holloway: The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
Barbara S. Coulson: The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
Mark von Itzstein: Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia
Thomas Haselhorst: Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia

Nature Communications, 2015, vol. 6, issue 1, 1-12

Abstract: Abstract Histo-blood group antigens (HBGAs) have been proposed as rotavirus receptors. H type-1 and Lewisb antigens have been reported to bind VP8* from major human rotavirus genotypes P[4], P[6] and P[8], while VP8* from a rarer P[14] rotavirus recognizes A-type HBGAs. However, the role and significance of HBGA receptors in rotavirus pathogenesis remains uncertain. Here we report that P[14] rotavirus HAL1166 and the related P[9] human rotavirus K8 bind to A-type HBGAs, although neither virus engages the HBGA-specific α1,2-linked fucose moiety. Notably, human rotaviruses DS-1 (P[4]) and RV-3 (P[6]) also use A-type HBGAs for infection, with fucose involvement. However, human P[8] rotavirus Wa does not recognize A-type HBGAs. Furthermore, the common human rotaviruses that we have investigated do not use Lewisb and H type-1 antigens. Our results indicate that A-type HBGAs are receptors for human rotaviruses, although rotavirus strains vary in their ability to recognize these antigens.

Date: 2015
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DOI: 10.1038/ncomms6907

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