Co-infection alters population dynamics of infectious disease

Hanna Susi, Benoit Barrès, Pedro F. Vale and Anna-Liisa Laine ()
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Hanna Susi: Metapopulation Research Group, University of Helsinki
Benoit Barrès: Metapopulation Research Group, University of Helsinki
Pedro F. Vale: Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh
Anna-Liisa Laine: Metapopulation Research Group, University of Helsinki

Nature Communications, 2015, vol. 6, issue 1, 1-8

Abstract: Abstract Co-infections by multiple pathogen strains are common in the wild. Theory predicts co-infections to have major consequences for both within- and between-host disease dynamics, but data are currently scarce. Here, using common garden populations of Plantago lanceolata infected by two strains of the pathogen Podosphaera plantaginis, either singly or under co-infection, we find the highest disease prevalence in co-infected treatments both at the host genotype and population levels. A spore-trapping experiment demonstrates that co-infected hosts shed more transmission propagules than singly infected hosts, thereby explaining the observed change in epidemiological dynamics. Our experimental findings are confirmed in natural pathogen populations—more devastating epidemics were measured in populations with higher levels of co-infection. Jointly, our results confirm the predictions made by theoretical and experimental studies for the potential of co-infection to alter disease dynamics across a large host–pathogen metapopulation.

Date: 2015
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DOI: 10.1038/ncomms6975

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