PD-L1hi B cells are critical regulators of humoral immunity

Adnan R. Khan, Emily Hams, Achilleas Floudas, Tim Sparwasser, Casey T. Weaver and Padraic G. Fallon ()
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Adnan R. Khan: Translational Immunology Group, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin
Emily Hams: Translational Immunology Group, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin
Achilleas Floudas: Translational Immunology Group, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin
Tim Sparwasser: Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI)
Casey T. Weaver: University of Alabama
Padraic G. Fallon: Translational Immunology Group, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin

Nature Communications, 2015, vol. 6, issue 1, 1-16

Abstract: Abstract Specific B-cell subsets can regulate T-cell immune responses, and are termed regulatory B cells (Breg). The majority of Breg cells described in mouse and man have been identified by IL-10 production and are known to suppress allergy and autoimmunity. However, Breg cell mediated immune suppression, independent of IL-10, also occurs. Here we show that Breg cells play a critical role in regulating humoral immunity mediated by CD4+CXCR5+PD-1+ follicular helper T cells, and can suppress inflammation in autoimmune disease through elevated expression of PD-L1. We have also identified that these B cells are resistant to αCD20 B-cell depletion. This work describes how Breg cells are critical in humoral homoeostasis and may have implications for the regulation of autoimmune diseases.

Date: 2015
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DOI: 10.1038/ncomms6997

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