Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids

Michael E. Kurczy, Zheng-Jiang Zhu, Julijana Ivanisevic, Adam M. Schuyler, Kush Lalwani, Antonio F. Santidrian, John M. David, Anand Giddabasappa, Amanda J. Roberts, Hernando J. Olivos, Peter J. O’Brien, Lauren Franco, Matthew W. Fields, Liliana P. Paris, Martin Friedlander, Caroline H. Johnson, Adrian A. Epstein, Howard E. Gendelman, Malcolm R. Wood, Brunhilde H. Felding, Gary J. Patti, Mary E. Spilker and Gary Siuzdak ()
Additional contact information
Michael E. Kurczy: Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute
Zheng-Jiang Zhu: Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute
Julijana Ivanisevic: Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute
Adam M. Schuyler: Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute
Kush Lalwani: Pfizer Worldwide Research and Development
Antonio F. Santidrian: The Scripps Research Institute
John M. David: Pfizer Worldwide Research and Development
Anand Giddabasappa: Pfizer Worldwide Research and Development
Amanda J. Roberts: The Scripps Research Institute
Hernando J. Olivos: Waters Corporation, 100 Cummings Center
Peter J. O’Brien: Pfizer Worldwide Research and Development
Lauren Franco: Montana State University
Matthew W. Fields: Montana State University
Liliana P. Paris: The Scripps Research Institute
Martin Friedlander: The Scripps Research Institute
Caroline H. Johnson: Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute
Adrian A. Epstein: University of Nebraska Medical Center
Howard E. Gendelman: University of Nebraska Medical Center
Malcolm R. Wood: The Core Microscopy Facility, The Scripps Research Institute
Brunhilde H. Felding: The Scripps Research Institute
Gary J. Patti: Washington University in St. Louis, One Brookings Drive
Mary E. Spilker: Pfizer Worldwide Research and Development
Gary Siuzdak: Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute

Nature Communications, 2015, vol. 6, issue 1, 1-8

Abstract: Abstract Fluorocarbons are lipophobic and non-polar molecules that exhibit remarkable biocompatibility, with applications in liquid ventilation and synthetic blood. The unique properties of these compounds have also enabled mass spectrometry imaging of tissues where the fluorocarbons act as a Teflon-like coating for nanostructured surfaces to assist in desorption/ionization. Here we report fluorinated gold nanoparticles (f-AuNPs) designed to facilitate nanostructure imaging mass spectrometry. Irradiation of f-AuNPs results in the release of the fluorocarbon ligands providing a driving force for analyte desorption. The f-AuNPs allow for the mass spectrometry analysis of both lipophilic and polar (central carbon) metabolites. An important property of AuNPs is that they also act as contrast agents for X-ray microtomography and electron microscopy, a feature we have exploited by infusing f-AuNPs into tissue via fluorocarbon liquids to facilitate multimodal (molecular and anatomical) imaging.

Date: 2015
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DOI: 10.1038/ncomms6998

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