Different forms of effective connectivity in primate frontotemporal pathways

Christopher I. Petkov (), Yukiko Kikuchi, Alice E. Milne, Mortimer Mishkin, Josef P. Rauschecker and Nikos K. Logothetis
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Christopher I. Petkov: Institute of Neuroscience, Framlington Place, Newcastle University
Yukiko Kikuchi: Institute of Neuroscience, Framlington Place, Newcastle University
Alice E. Milne: Institute of Neuroscience, Framlington Place, Newcastle University
Mortimer Mishkin: Laboratory of Neuropsychology, NIMH, NIH
Josef P. Rauschecker: Georgetown University Medical Center
Nikos K. Logothetis: Max Planck Institute for Biological Cybernetics

Nature Communications, 2015, vol. 6, issue 1, 1-13

Abstract: Abstract It is generally held that non-primary sensory regions of the brain have a strong impact on frontal cortex. However, the effective connectivity of pathways to frontal cortex is poorly understood. Here we microstimulate sites in the superior temporal and ventral frontal cortex of monkeys and use functional magnetic resonance imaging to evaluate the functional activity resulting from the stimulation of interconnected regions. Surprisingly, we find that, although certain earlier stages of auditory cortical processing can strongly activate frontal cortex, downstream auditory regions, such as voice-sensitive cortex, appear to functionally engage primarily an ipsilateral temporal lobe network. Stimulating other sites within this activated temporal lobe network shows strong activation of frontal cortex. The results indicate that the relative stage of sensory processing does not predict the level of functional access to the frontal lobes. Rather, certain brain regions engage local networks, only parts of which have a strong functional impact on frontal cortex.

Date: 2015
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DOI: 10.1038/ncomms7000

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