Temporal and spatial regulation of translation in the mammalian oocyte via the mTOR–eIF4F pathway

Andrej Susor (), Denisa Jansova, Renata Cerna, Anna Danylevska, Martin Anger, Tereza Toralova, Radek Malik, Jaroslava Supolikova, Matthew S. Cook, Jeong Su Oh and Michal Kubelka
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Andrej Susor: Institute of Animal Physiology and Genetics, ASCR
Denisa Jansova: Institute of Animal Physiology and Genetics, ASCR
Renata Cerna: Institute of Animal Physiology and Genetics, ASCR
Anna Danylevska: CEITEC-Veterinary Research Institute
Martin Anger: Institute of Animal Physiology and Genetics, ASCR
Tereza Toralova: Institute of Animal Physiology and Genetics, ASCR
Radek Malik: Institute of Molecular Genetics, ASCR
Jaroslava Supolikova: Institute of Animal Physiology and Genetics, ASCR
Matthew S. Cook: The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF
Jeong Su Oh: Sungkyunkwan University
Michal Kubelka: Institute of Animal Physiology and Genetics, ASCR

Nature Communications, 2015, vol. 6, issue 1, 1-12

Abstract: Abstract The fully grown mammalian oocyte is transcriptionally quiescent and utilizes only transcripts synthesized and stored during early development. However, we find that an abundant RNA population is retained in the oocyte nucleus and contains specific mRNAs important for meiotic progression. Here we show that during the first meiotic division, shortly after nuclear envelope breakdown, translational hotspots develop in the chromosomal area and in a region that was previously surrounded the nucleus. These distinct translational hotspots are separated by endoplasmic reticulum and Lamin, and disappear following polar body extrusion. Chromosomal translational hotspots are controlled by the activity of the mTOR–eIF4F pathway. Here we reveal a mechanism that—following the resumption of meiosis—controls the temporal and spatial translation of a specific set of transcripts required for normal spindle assembly, chromosome alignment and segregation.

Date: 2015
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DOI: 10.1038/ncomms7078

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