Vaginal type-II mucosa is an inductive site for primary CD8+ T-cell mucosal immunity

Yichuan Wang, Yongjun Sui (), Shingo Kato, Alison E. Hogg, Jason C. Steel, John C. Morris and Jay A. Berzofsky ()
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Yichuan Wang: Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health
Yongjun Sui: Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health
Shingo Kato: Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health
Alison E. Hogg: Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health
Jason C. Steel: The University of Queensland
John C. Morris: University of Cincinnati Cancer Institute
Jay A. Berzofsky: Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health

Nature Communications, 2015, vol. 6, issue 1, 1-13

Abstract: Abstract The structured lymphoid tissues are considered the only inductive sites where primary T-cell immune responses occur. The naïve T cells in structured lymphoid tissues, once being primed by antigen-bearing dendritic cells, differentiate into memory T cells and traffic back to the mucosal sites through the bloodstream. Contrary to this belief, here we show that the vaginal type-II mucosa itself, despite the lack of structured lymphoid tissues, can act as an inductive site during primary CD8+ T-cell immune responses. We provide evidence that the vaginal mucosa supports both the local immune priming of naïve CD8+ T cells and the local expansion of antigen-specific CD8+ T cells, thereby demonstrating a different paradigm for primary mucosal T-cell immune induction.

Date: 2015
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DOI: 10.1038/ncomms7100

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