Genetic blueprint of the zoonotic pathogen Toxocara canis

Xing-Quan Zhu (), Pasi K. Korhonen (), Huimin Cai, Neil D. Young, Peter Nejsum, Georg von Samson-Himmelstjerna, Peter R. Boag, Patrick Tan, Qiye Li, Jiumeng Min, Yulan Yang, Xiuhua Wang, Xiaodong Fang, Ross S. Hall, Andreas Hofmann, Paul W. Sternberg, Aaron R. Jex and Robin B. Gasser ()
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Xing-Quan Zhu: State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
Pasi K. Korhonen: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne
Huimin Cai: BGI
Neil D. Young: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne
Peter Nejsum: University of Copenhagen
Georg von Samson-Himmelstjerna: Institute for Parasitology und Tropical Veterinary Medicine, Freie Universität Berlin
Peter R. Boag: Monash University
Patrick Tan: Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School
Qiye Li: BGI
Jiumeng Min: BGI
Yulan Yang: BGI
Xiuhua Wang: BGI
Xiaodong Fang: BGI
Ross S. Hall: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne
Andreas Hofmann: Structural Chemistry Program, Eskitis Institute, Griffith University
Paul W. Sternberg: HHMI, California Institute of Technology
Aaron R. Jex: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne
Robin B. Gasser: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne

Nature Communications, 2015, vol. 6, issue 1, 1-8

Abstract: Abstract Toxocara canis is a zoonotic parasite of major socioeconomic importance worldwide. In humans, this nematode causes disease (toxocariasis) mainly in the under-privileged communities in developed and developing countries. Although relatively well studied from clinical and epidemiological perspectives, to date, there has been no global investigation of the molecular biology of this parasite. Here we use next-generation sequencing to produce a draft genome and transcriptome of T. canis to support future biological and biotechnological investigations. This genome is 317 Mb in size, has a repeat content of 13.5% and encodes at least 18,596 protein-coding genes. We study transcription in a larval, as well as adult female and male stages, characterize the parasite’s gene-silencing machinery, explore molecules involved in development or host–parasite interactions and predict intervention targets. The draft genome of T. canis should provide a useful resource for future molecular studies of this and other, related parasites.

Date: 2015
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DOI: 10.1038/ncomms7145

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