Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence

Régis Joulia, Nicolas Gaudenzio, Magda Rodrigues, Jodie Lopez, Nicolas Blanchard, Salvatore Valitutti and Eric Espinosa ()
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Régis Joulia: Inserm, U1043, Toulouse F-31300, France; Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP)
Nicolas Gaudenzio: Inserm, U1043, Toulouse F-31300, France; Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP)
Magda Rodrigues: Inserm, U1043, Toulouse F-31300, France; Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP)
Jodie Lopez: Inserm, U1043, Toulouse F-31300, France; Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP)
Nicolas Blanchard: Inserm, U1043, Toulouse F-31300, France; Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP)
Salvatore Valitutti: Inserm, U1043, Toulouse F-31300, France; Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP)
Eric Espinosa: Inserm, U1043, Toulouse F-31300, France; Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP)

Nature Communications, 2015, vol. 6, issue 1, 1-12

Abstract: Abstract Mast cells are tissue-resident immune cells that play a key role in inflammation and allergy. Here we show that interaction of mast cells with antibody-targeted cells induces the polarized exocytosis of their granules resulting in a sustained exposure of effector enzymes, such as tryptase and chymase, at the cell–cell contact site. This previously unidentified mast cell effector mechanism, which we name the antibody-dependent degranulatory synapse (ADDS), is triggered by both IgE- and IgG-targeted cells. ADDSs take place within an area of cortical actin cytoskeleton clearance in the absence of microtubule organizing centre and Golgi apparatus repositioning towards the stimulating cell. Remarkably, IgG-mediated degranulatory synapses also occur upon contact with opsonized Toxoplasma gondii tachyzoites resulting in tryptase-dependent parasite death. Our results broaden current views of mast cell degranulation by revealing that human mast cells form degranulatory synapses with antibody-targeted cells and pathogens for dedicated secretion and defence.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7174

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DOI: 10.1038/ncomms7174

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