Primitive macrophages control HSPC mobilization and definitive haematopoiesis

Jana Travnickova, Vanessa Tran Chau, Emmanuelle Julien, Julio Mateos-Langerak, Catherine Gonzalez, Etienne Lelièvre, Georges Lutfalla, Manuela Tavian and Karima Kissa ()
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Jana Travnickova: CNRS UMR 5235
Vanessa Tran Chau: CNRS UMR 5235
Emmanuelle Julien: INSERM UMR_S949
Julio Mateos-Langerak: Montpellier RIO Imaging
Catherine Gonzalez: CNRS UMR 5235
Etienne Lelièvre: CNRS UMR 5235
Georges Lutfalla: CNRS UMR 5235
Manuela Tavian: INSERM UMR_S949
Karima Kissa: CNRS UMR 5235

Nature Communications, 2015, vol. 6, issue 1, 1-9

Abstract: Abstract In vertebrates, haematopoietic stem/progenitor cells (HSPCs) first emerge in the aorta–gonad–mesonephros (AGM) before colonizing transitory and subsequently definitive haematopoietic organs allowing haematopoiesis throughout adult life. Here we identify an unexpected primitive macrophage population accumulated in the dorsal mesenteric mesoderm surrounding the dorsal aorta of the human embryo and study its function in the transparent zebrafish embryo. Our study reveals dynamic interactions occurring between the HSPCs and primitive macrophages in the AGM. Specific chemical and inducible genetic depletion of macrophages or inhibition of matrix metalloproteinases (Mmps) leads to an accumulation of HSPCs in the AGM and a decrease in the colonization of haematopoietic organs. Finally, in vivo zymography demonstrates the function of primitive macrophages in extracellular matrix degradation, which allows HSPC migration through the AGM stroma, their intravasation, leading to the colonization of haematopoietic organs and the establishment of definitive haematopoiesis.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7227

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DOI: 10.1038/ncomms7227

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