Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival

Dennis S. Rice, Jorgelina M. Calandria, William C. Gordon, Bokkyoo Jun, Yongdong Zhou, Claire M. Gelfman, Songhua Li, Minghao Jin, Eric J. Knott, Bo Chang, Alex Abuin, Tawfik Issa, David Potter, Kenneth A. Platt and Nicolas G. Bazan ()
Additional contact information
Dennis S. Rice: Lexicon Pharmaceuticals
Jorgelina M. Calandria: Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center
William C. Gordon: Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center
Bokkyoo Jun: Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center
Yongdong Zhou: Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center
Claire M. Gelfman: Lexicon Pharmaceuticals
Songhua Li: Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center
Minghao Jin: Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center
Eric J. Knott: Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center
Bo Chang: The Jackson Laboratory
Alex Abuin: Lexicon Pharmaceuticals
Tawfik Issa: Lexicon Pharmaceuticals
David Potter: Lexicon Pharmaceuticals
Kenneth A. Platt: Lexicon Pharmaceuticals
Nicolas G. Bazan: Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center

Nature Communications, 2015, vol. 6, issue 1, 1-15

Abstract: Abstract The identification of pathways necessary for photoreceptor and retinal pigment epithelium (RPE) function is critical to uncover therapies for blindness. Here we report the discovery of adiponectin receptor 1 (AdipoR1) as a regulator of these cells’ functions. Docosahexaenoic acid (DHA) is avidly retained in photoreceptors, while mechanisms controlling DHA uptake and retention are unknown. Thus, we demonstrate that AdipoR1 ablation results in DHA reduction. In situ hybridization reveals photoreceptor and RPE cell AdipoR1 expression, blunted in AdipoR1−/− mice. We also find decreased photoreceptor-specific phosphatidylcholine containing very long-chain polyunsaturated fatty acids and severely attenuated electroretinograms. These changes precede progressive photoreceptor degeneration in AdipoR1−/− mice. RPE-rich eyecup cultures from AdipoR1−/− reveal impaired DHA uptake. AdipoR1 overexpression in RPE cells enhances DHA uptake, whereas AdipoR1 silencing has the opposite effect. These results establish AdipoR1 as a regulatory switch of DHA uptake, retention, conservation and elongation in photoreceptors and RPE, thus preserving photoreceptor cell integrity.

Date: 2015
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DOI: 10.1038/ncomms7228

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