Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci

Mathieu Lemire (), Syed H.E. Zaidi, Maria Ban, Bing Ge, Dylan Aïssi, Marine Germain, Irfahan Kassam, Mike Wang, Brent W. Zanke, France Gagnon, Pierre-Emmanuel Morange, David-Alexandre Trégouët, Philip S. Wells, Stephen Sawcer, Steven Gallinger, Tomi Pastinen and Thomas J. Hudson
Additional contact information
Mathieu Lemire: Ontario Institute for Cancer Research
Syed H.E. Zaidi: Ontario Institute for Cancer Research
Maria Ban: University of Cambridge
Bing Ge: McGill University and Genome Québec Innovation Centre
Dylan Aïssi: INSERM, UMR-S 1166
Marine Germain: INSERM, UMR-S 1166
Irfahan Kassam: Dalla Lana School of Public Health, University of Toronto
Mike Wang: Ontario Institute for Cancer Research
Brent W. Zanke: University of Ottawa, Ottawa Hospital Research Institute
France Gagnon: Dalla Lana School of Public Health, University of Toronto
Pierre-Emmanuel Morange: Laboratory of Haematology, La Timone Hospital
David-Alexandre Trégouët: INSERM, UMR-S 1166
Philip S. Wells: University of Ottawa, Ottawa Hospital Research Institute
Stephen Sawcer: University of Cambridge
Steven Gallinger: Samuel Lunenfeld Research Institute
Tomi Pastinen: McGill University and Genome Québec Innovation Centre
Thomas J. Hudson: Ontario Institute for Cancer Research

Nature Communications, 2015, vol. 6, issue 1, 1-12

Abstract: Abstract The interplay between genetic and epigenetic variation is only partially understood. One form of epigenetic variation is methylation at CpG sites, which can be measured as methylation quantitative trait loci (meQTL). Here we report that in a panel of lymphocytes from 1,748 individuals, methylation levels at 1,919 CpG sites are correlated with at least one distal (trans) single-nucleotide polymorphism (SNP) (P 1 Mb apart. Over 90% of these pairs are replicated (FDR

Date: 2015
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/ncomms7326 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7326

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms7326

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().