In vivo odourant response properties of migrating adult-born neurons in the mouse olfactory bulb

Yury Kovalchuk, Ryota Homma, Yajie Liang, Anatoliy Maslyukov, Marina Hermes, Thomas Thestrup, Oliver Griesbeck, Jovica Ninkovic, Lawrence B. Cohen and Olga Garaschuk ()
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Yury Kovalchuk: Institute of Physiology II, University of Tübingen, Keplerstrasse 15, 72074 Tübingen, Germany
Ryota Homma: Yale University
Yajie Liang: Institute of Physiology II, University of Tübingen, Keplerstrasse 15, 72074 Tübingen, Germany
Anatoliy Maslyukov: Institute of Physiology II, University of Tübingen, Keplerstrasse 15, 72074 Tübingen, Germany
Marina Hermes: Institute of Physiology II, University of Tübingen, Keplerstrasse 15, 72074 Tübingen, Germany
Thomas Thestrup: Max Planck Institute of Neurobiology
Oliver Griesbeck: Max Planck Institute of Neurobiology
Jovica Ninkovic: Helmholtz Zentrum München, Institute of Stem Cell Research
Lawrence B. Cohen: Yale University
Olga Garaschuk: Institute of Physiology II, University of Tübingen, Keplerstrasse 15, 72074 Tübingen, Germany

Nature Communications, 2015, vol. 6, issue 1, 1-12

Abstract: Abstract Juxtaglomerular neurons (JGNs) of the mammalian olfactory bulb are generated throughout life. Their integration into the preexisting neural network, their differentiation and survival therein depend on sensory activity, but when and how these adult-born cells acquire responsiveness to sensory stimuli remains unknown. In vivo two-photon imaging of retrovirally labelled adult-born JGNs reveals that ~90% of the cells arrive at the glomerular layer after day post injection (DPI) 7. After arrival, adult-born JGNs are still migrating, but at DPI 9, 52% of them have odour-evoked Ca2+ signals. Their odourant sensitivity closely resembles that of the parent glomerulus and surrounding JGNs, and their spontaneous and odour-evoked spiking is similar to that of their resident neighbours. Our data reveal a remarkably rapid functional integration of adult-born cells into the preexisting neural network. The mature pattern of odour-evoked responses of these cells strongly contrasts with their molecular phenotype, which is typical of immature, migrating neuroblasts.

Date: 2015
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DOI: 10.1038/ncomms7349

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