Epigenetic and transcriptional determinants of the human breast

Philippe Gascard, Misha Bilenky, Mahvash Sigaroudinia, Jianxin Zhao, Luolan Li, Annaick Carles, Allen Delaney, Angela Tam, Baljit Kamoh, Stephanie Cho, Malachi Griffith, Andy Chu, Gordon Robertson, Dorothy Cheung, Irene Li, Alireza Heravi-Moussavi, Michelle Moksa, Matthew Mingay, Angela Hussainkhel, Brad Davis, Raman P. Nagarajan, Chibo Hong, Lorigail Echipare, Henriette O’Geen, Matthew J. Hangauer, Jeffrey B. Cheng, Dana Neel, Donglei Hu, Michael T. McManus, Richard Moore, Andrew Mungall, Yussanne Ma, Patrick Plettner, Elad Ziv, Ting Wang, Peggy J. Farnham, Steven J.M. Jones, Marco A. Marra, Thea D. Tlsty, Joseph F. Costello and Martin Hirst ()
Additional contact information
Philippe Gascard: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Misha Bilenky: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Mahvash Sigaroudinia: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Jianxin Zhao: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Luolan Li: University of British Columbia
Annaick Carles: University of British Columbia
Allen Delaney: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Angela Tam: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Baljit Kamoh: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Stephanie Cho: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Malachi Griffith: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Andy Chu: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Gordon Robertson: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Dorothy Cheung: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Irene Li: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Alireza Heravi-Moussavi: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Michelle Moksa: University of British Columbia
Matthew Mingay: University of British Columbia
Angela Hussainkhel: University of British Columbia
Brad Davis: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Raman P. Nagarajan: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Chibo Hong: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Lorigail Echipare: The Genome Center, University of California-Davis
Henriette O’Geen: The Genome Center, University of California-Davis
Matthew J. Hangauer: UCSF Diabetes Center, University of California San Francisco
Jeffrey B. Cheng: University of California San Francisco
Dana Neel: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Donglei Hu: Institute for Human Genetics and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Michael T. McManus: UCSF Diabetes Center, University of California San Francisco
Richard Moore: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Andrew Mungall: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Yussanne Ma: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Patrick Plettner: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Elad Ziv: Institute for Human Genetics and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Ting Wang: School of Medicine, Washington University in St Louis
Peggy J. Farnham: Norris Comprehensive Cancer Center, University of Southern California
Steven J.M. Jones: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Marco A. Marra: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
Thea D. Tlsty: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Joseph F. Costello: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Martin Hirst: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency

Nature Communications, 2015, vol. 6, issue 1, 1-10

Abstract: Abstract While significant effort has been dedicated to the characterization of epigenetic changes associated with prenatal differentiation, relatively little is known about the epigenetic changes that accompany post-natal differentiation where fully functional differentiated cell types with limited lifespans arise. Here we sought to address this gap by generating epigenomic and transcriptional profiles from primary human breast cell types isolated from disease-free human subjects. From these data we define a comprehensive human breast transcriptional network, including a set of myoepithelial- and luminal epithelial-specific intronic retention events. Intersection of epigenetic states with RNA expression from distinct breast epithelium lineages demonstrates that mCpG provides a stable record of exonic and intronic usage, whereas H3K36me3 is dynamic. We find a striking asymmetry in epigenomic reprogramming between luminal and myoepithelial cell types, with the genomes of luminal cells harbouring more than twice the number of hypomethylated enhancer elements compared with myoepithelial cells.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms7351 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7351

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms7351

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().