Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence

Jyoti Parkash, Andrea Messina, Fanny Langlet, Irene Cimino, Anne Loyens, Danièle Mazur, Sarah Gallet, Eglantine Balland, Samuel A. Malone, François Pralong, Gabriella Cagnoni, Roberta Schellino, Silvia De Marchis, Massimiliano Mazzone, R. Jeroen Pasterkamp, Luca Tamagnone, Vincent Prevot and Paolo Giacobini ()
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Jyoti Parkash: Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
Andrea Messina: Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
Fanny Langlet: Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
Irene Cimino: Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
Anne Loyens: Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
Danièle Mazur: Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
Sarah Gallet: Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
Eglantine Balland: Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
Samuel A. Malone: Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
François Pralong: Service of Endocrinology, Diabetology and Metabolism, Faculty of Biology and Medicine, University Hospital
Gabriella Cagnoni: Candiolo Cancer Institute—FPO, IRCCS
Roberta Schellino: University of Torino
Silvia De Marchis: University of Torino
Massimiliano Mazzone: Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB
R. Jeroen Pasterkamp: Brain Center Rudolf Magnus, University Medical Center Utrecht
Luca Tamagnone: Candiolo Cancer Institute—FPO, IRCCS
Vincent Prevot: Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
Paolo Giacobini: Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre

Nature Communications, 2015, vol. 6, issue 1, 1-17

Abstract: Abstract Reproductive competence in mammals depends on the projection of gonadotropin-releasing hormone (GnRH) neurons to the hypothalamic median eminence (ME) and the timely release of GnRH into the hypothalamic–pituitary–gonadal axis. In adult rodents, GnRH neurons and the specialized glial cells named tanycytes periodically undergo cytoskeletal plasticity. However, the mechanisms that regulate this plasticity are still largely unknown. We demonstrate that Semaphorin7A, expressed by tanycytes, plays a dual role, inducing the retraction of GnRH terminals and promoting their ensheathment by tanycytic end feet via the receptors PlexinC1 and Itgb1, respectively. Moreover, Semaphorin7A expression is regulated during the oestrous cycle by the fluctuating levels of gonadal steroids. Genetic invalidation of Semaphorin7A receptors in mice induces neuronal and glial rearrangements in the ME and abolishes normal oestrous cyclicity and fertility. These results show a role for Semaphorin7A signalling in mediating periodic neuroglial remodelling in the adult ME during the ovarian cycle.

Date: 2015
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DOI: 10.1038/ncomms7385

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