Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

Mohammed Eslam, Ahmed M. Hashem, Reynold Leung, Manuel Romero-Gomez, Thomas Berg, Gregory J. Dore, Henry L.K. Chan, William L. Irving, David Sheridan, Maria L. Abate, Leon A. Adams, Alessandra Mangia, Martin Weltman, Elisabetta Bugianesi, Ulrich Spengler, Olfat Shaker, Janett Fischer, Lindsay Mollison, Wendy Cheng, Elizabeth Powell, Jacob Nattermann, Stephen Riordan, Duncan McLeod, Nicola J. Armstrong, Mark W. Douglas, Christopher Liddle, David R. Booth, Jacob George () and Golo Ahlenstiel
Additional contact information
Mohammed Eslam: Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney
Ahmed M. Hashem: Faculty of Engineering, Minia University
Reynold Leung: Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney
Manuel Romero-Gomez: Unit for The Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme
Thomas Berg: Medizinische Klinik m.S. Hepatologie und Gastroenterologie, Charite, Campus Virchow-Klinikum, Universitätsmedizin Berlin
Gregory J. Dore: Kirby Institute, The University of New South Wales
Henry L.K. Chan: Prince of Wales Hospital, The Chinese University of Hong Kong
William L. Irving: NIHR Biomedical Research Unit in Gastroenterology and the Liver, University of Nottingham
David Sheridan: Liver Research Group, Institute of Cellular Medicine, Medical School, Newcastle University
Maria L. Abate: University of Turin
Leon A. Adams: School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, University of Western Australia
Alessandra Mangia: Ospedale Casa Sollievo della Sofferenza, IRCCS
Martin Weltman: Nepean Hospital
Elisabetta Bugianesi: University of Turin
Ulrich Spengler: University of Bonn
Olfat Shaker: Faculty of Medicine, Cairo University
Janett Fischer: Medizinische Klinik m.S. Hepatologie und Gastroenterologie, Charite, Campus Virchow-Klinikum, Universitätsmedizin Berlin
Lindsay Mollison: Fremantle Hospital
Wendy Cheng: Royal Perth Hospital
Elizabeth Powell: Princess Alexandra Hospital
Jacob Nattermann: University of Bonn
Stephen Riordan: Gastrointestinal and Liver Unit, Prince of Wales Hospital and University of New South Wales
Duncan McLeod: Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital
Nicola J. Armstrong: School of Mathematics and Statistics, University of Sydney
Mark W. Douglas: Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney
Christopher Liddle: Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney
David R. Booth: Institute of Immunology and Allergy Research, Westmead Hospital and Westmead Millennium Institute, University of Sydney
Jacob George: Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney
Golo Ahlenstiel: Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney

Nature Communications, 2015, vol. 6, issue 1, 1-10

Abstract: Abstract Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a cohort of 4,172 patients, including 3,129 with chronic hepatitis C (CHC), 555 with chronic hepatitis B (CHB) and 488 with non-alcoholic fatty liver disease (NAFLD), those with rs12979860CC have greater hepatic inflammation and fibrosis. In CHC, those with rs12979860CC also have greater stage-constant and stage-specific fibrosis progression rates (P

Date: 2015
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DOI: 10.1038/ncomms7422

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