Gut microbiome development along the colorectal adenoma–carcinoma sequence

Qiang Feng, Suisha Liang, Huijue Jia, Andreas Stadlmayr, Longqing Tang, Zhou Lan, Dongya Zhang, Huihua Xia, Xiaoying Xu, Zhuye Jie, Lili Su, Xiaoping Li, Xin Li, Junhua Li, Liang Xiao, Ursula Huber-Schönauer, David Niederseer, Xun Xu, Jumana Yousuf Al-Aama, Huanming Yang, Jian Wang, Karsten Kristiansen, Manimozhiyan Arumugam, Herbert Tilg (), Christian Datz () and Jun Wang ()
Additional contact information
Qiang Feng: BGI-Shenzhen
Suisha Liang: BGI-Shenzhen
Huijue Jia: BGI-Shenzhen
Andreas Stadlmayr: Hospital Oberndorf, Teaching Hospital of the Paracelsus Private University of Salzburg
Longqing Tang: BGI-Shenzhen
Zhou Lan: BGI-Shenzhen
Dongya Zhang: BGI-Shenzhen
Huihua Xia: BGI-Shenzhen
Xiaoying Xu: BGI-Shenzhen
Zhuye Jie: BGI-Shenzhen
Lili Su: BGI-Shenzhen
Xiaoping Li: BGI-Shenzhen
Xin Li: BGI-Shenzhen
Junhua Li: BGI-Shenzhen
Liang Xiao: BGI-Shenzhen
Ursula Huber-Schönauer: Hospital Oberndorf, Teaching Hospital of the Paracelsus Private University of Salzburg
David Niederseer: Hospital Oberndorf, Teaching Hospital of the Paracelsus Private University of Salzburg
Xun Xu: BGI-Shenzhen
Jumana Yousuf Al-Aama: BGI-Shenzhen
Huanming Yang: BGI-Shenzhen
Jian Wang: BGI-Shenzhen
Karsten Kristiansen: BGI-Shenzhen
Manimozhiyan Arumugam: BGI-Shenzhen
Herbert Tilg: Medical University Innsbruck
Christian Datz: Hospital Oberndorf, Teaching Hospital of the Paracelsus Private University of Salzburg
Jun Wang: BGI-Shenzhen

Nature Communications, 2015, vol. 6, issue 1, 1-13

Abstract: Abstract Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved in colorectal carcinogenesis. The identity and functional capacity of the adenoma- or carcinoma-related gut microbe(s), however, have not been surveyed in a comprehensive manner. Here we perform a metagenome-wide association study (MGWAS) on stools from advanced adenoma and carcinoma patients and from healthy subjects, revealing microbial genes, strains and functions enriched in each group. An analysis of potential risk factors indicates that high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. These findings suggest that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma.

Date: 2015
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DOI: 10.1038/ncomms7528

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