A graphene field-effect transistor as a molecule-specific probe of DNA nucleobases

Nikolai Dontschuk (), Alastair Stacey, Anton Tadich, Kevin J. Rietwyk, Alex Schenk, Mark T. Edmonds, Olga Shimoni, Chris I. Pakes, Steven Prawer () and Jiri Cervenka ()
Additional contact information
Nikolai Dontschuk: The School of Physics, The University of Melbourne
Alastair Stacey: The School of Physics, The University of Melbourne
Anton Tadich: Australian Synchrotron
Kevin J. Rietwyk: La Trobe University
Alex Schenk: La Trobe University
Mark T. Edmonds: La Trobe University
Olga Shimoni: The School of Physics, The University of Melbourne
Chris I. Pakes: La Trobe University
Steven Prawer: The School of Physics, The University of Melbourne
Jiri Cervenka: The School of Physics, The University of Melbourne

Nature Communications, 2015, vol. 6, issue 1, 1-7

Abstract: Abstract Fast and reliable DNA sequencing is a long-standing target in biomedical research. Recent advances in graphene-based electrical sensors have demonstrated their unprecedented sensitivity to adsorbed molecules, which holds great promise for label-free DNA sequencing technology. To date, the proposed sequencing approaches rely on the ability of graphene electric devices to probe molecular-specific interactions with a graphene surface. Here we experimentally demonstrate the use of graphene field-effect transistors (GFETs) as probes of the presence of a layer of individual DNA nucleobases adsorbed on the graphene surface. We show that GFETs are able to measure distinct coverage-dependent conductance signatures upon adsorption of the four different DNA nucleobases; a result that can be attributed to the formation of an interface dipole field. Comparison between experimental GFET results and synchrotron-based material analysis allowed prediction of the ultimate device sensitivity, and assessment of the feasibility of single nucleobase sensing with graphene.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms7563 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7563

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms7563

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().