Rational design of a chalcogenopyrylium-based surface-enhanced resonance Raman scattering nanoprobe with attomolar sensitivity

Stefan Harmsen, Matthew A. Bedics, Matthew A. Wall, Ruimin Huang, Michael R. Detty () and Moritz F. Kircher ()
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Stefan Harmsen: Memorial Sloan Kettering Cancer Center
Matthew A. Bedics: University at Buffalo, The State University of New York
Matthew A. Wall: Memorial Sloan Kettering Cancer Center
Ruimin Huang: Memorial Sloan Kettering Cancer Center
Michael R. Detty: University at Buffalo, The State University of New York
Moritz F. Kircher: Memorial Sloan Kettering Cancer Center

Nature Communications, 2015, vol. 6, issue 1, 1-9

Abstract: Abstract High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here we report the design and synthesis of a group of near-infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to have high affinity for gold. When adsorbed onto gold nanoparticles, these dyes produce biocompatible SERRS nanoprobes with attomolar limits of detection amenable to ultrasensitive in vivo multiplexed tumour and disease marker detection.

Date: 2015
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DOI: 10.1038/ncomms7570

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