Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis

Lucy A. Weinert (), Roy R. Chaudhuri, Jinhong Wang, Sarah E. Peters, Jukka Corander, Thibaut Jombart, Abiyad Baig, Kate J. Howell, Minna Vehkala, Niko Välimäki, David Harris, Tran Thi Bich Chieu, Nguyen Van Vinh Chau, James Campbell, Constance Schultsz, Julian Parkhill, Stephen D. Bentley, Paul R. Langford, Andrew N. Rycroft, Brendan W. Wren, Jeremy Farrar, Stephen Baker, Ngo Thi Hoa, Matthew T.G. Holden, Alexander W. Tucker () and Duncan J. Maskell
Additional contact information
Lucy A. Weinert: University of Cambridge
Roy R. Chaudhuri: University of Sheffield
Jinhong Wang: University of Cambridge
Sarah E. Peters: University of Cambridge
Jukka Corander: University of Helsinki
Thibaut Jombart: MRC Centre for Outbreak Analysis and Modelling, Faculty of Medicine
Abiyad Baig: University of Cambridge
Kate J. Howell: University of Cambridge
Minna Vehkala: University of Helsinki
Niko Välimäki: University of Helsinki
David Harris: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Tran Thi Bich Chieu: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases
Nguyen Van Vinh Chau: Hospital for Tropical Diseases
James Campbell: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases
Constance Schultsz: Academic Medical Centre, University of Amsterdam
Julian Parkhill: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Stephen D. Bentley: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Paul R. Langford: Section of Paediatrics, Faculty of Medicine, Imperial College London
Andrew N. Rycroft: The Royal Veterinary College, Hawkshead Campus
Brendan W. Wren: Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
Jeremy Farrar: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases
Stephen Baker: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases
Ngo Thi Hoa: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases
Matthew T.G. Holden: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Alexander W. Tucker: University of Cambridge
Duncan J. Maskell: University of Cambridge

Nature Communications, 2015, vol. 6, issue 1, 1-10

Abstract: Abstract Streptococcus suis causes disease in pigs worldwide and is increasingly implicated in zoonotic disease in East and South-East Asia. To understand the genetic basis of disease in S. suis, we study the genomes of 375 isolates with detailed clinical phenotypes from pigs and humans from the United Kingdom and Vietnam. Here, we show that isolates associated with disease contain substantially fewer genes than non-clinical isolates, but are more likely to encode virulence factors. Human disease isolates are limited to a single-virulent population, originating in the 1920, s when pig production was intensified, but no consistent genomic differences between pig and human isolates are observed. There is little geographical clustering of different S. suis subpopulations, and the bacterium undergoes high rates of recombination, implying that an increase in virulence anywhere in the world could have a global impact over a short timescale.

Date: 2015
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DOI: 10.1038/ncomms7740

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