Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production

Ryeojin Ko, Jin Hee Park, Hyunil Ha, Yongwon Choi and Soo Young Lee ()
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Ryeojin Ko: Ewha Womans University
Jin Hee Park: Ewha Womans University
Hyunil Ha: University of Pennsylvania Perelman School of Medicine
Yongwon Choi: University of Pennsylvania Perelman School of Medicine
Soo Young Lee: Ewha Womans University

Nature Communications, 2015, vol. 6, issue 1, 1-12

Abstract: Abstract TRAF6 is critical for the production of inflammatory cytokines in various TLR-mediated signalling pathways. However, it is poorly understood how TRAF6 regulates TLR3 responses. Here we demonstrate that GSK3β interacts with TRAF6 and positively regulates the TLR3-mediated signalling. Suppression of GSK3β expression or its kinase activity drastically reduces the production of inflammatory cytokines and the induction of c-Fos by decreasing ERK and p38 phosphorylation. GSK3β physically associates with TRAF6 in a TLR3 ligand poly I:C-dependent manner. TRAF6 is determined to be a direct E3 ligase for GSK3β, and TRAF6-mediated GSK3β ubiquitination is essential for poly I:C-dependent cytokine production by promoting the TLR3 adaptor protein TRIF-assembled signalling complex.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7765

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DOI: 10.1038/ncomms7765

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