APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p

Kun Wang, Cui-Yun Liu, Lu-Yu Zhou, Jian-Xun Wang, Man Wang, Bing Zhao, Wen-Ke Zhao, Shi-Jun Xu, Li-Hua Fan, Xiao-Jie Zhang, Chang Feng, Chao-Qun Wang, Yan-Fang Zhao and Pei-Feng Li ()
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Kun Wang: Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
Cui-Yun Liu: State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences
Lu-Yu Zhou: Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
Jian-Xun Wang: Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
Man Wang: Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
Bing Zhao: Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
Wen-Ke Zhao: Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
Shi-Jun Xu: Anzen Hospital, Beijing Institute of Heart Lung and Blood Vessel Diseases, Capital Medical University
Li-Hua Fan: State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences
Xiao-Jie Zhang: State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences
Chang Feng: State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences
Chao-Qun Wang: Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
Yan-Fang Zhao: Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University
Pei-Feng Li: Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University

Nature Communications, 2015, vol. 6, issue 1, 1-11

Abstract: Abstract The abnormal autophagy is associated with a variety of cardiovascular diseases. Long noncoding RNAs (lncRNAs) are emerging as new factors in gene regulation, but how lncRNAs operate in the regulation of autophagy in the heart is unclear. Here we report that a long noncoding RNA, named autophagy promoting factor (APF), can regulate autophagic cell death by targeting miR-188-3p and ATG7. The results show that miR-188-3p suppresses autophagy and myocardial infarction by targeting ATG7. Further, we find that APF lncRNA regulates miR-188-3p, and thus affects ATG7 expression, autophagic cell death and myocardial infarction. Our present study reveals a novel regulating model of autophagic programme, which comprises APF, miR-188-3p and ATG7 in the heart. Modulation of their levels may serve as potential targets and diagnostic tools for novel therapeutic strategies of myocardial infarction and heart failure.

Date: 2015
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DOI: 10.1038/ncomms7779

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