Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking

Jongshin Kim (), Haiin Jo, Hyowon Hong, Min Hwan Kim, Jin Man Kim, June-Koo Lee, Won Do Heo and Joon Kim
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Jongshin Kim: Graduate School of Medical Science and Engineering, KAIST
Haiin Jo: Graduate School of Medical Science and Engineering, KAIST
Hyowon Hong: Graduate School of Medical Science and Engineering, KAIST
Min Hwan Kim: Graduate School of Medical Science and Engineering, KAIST
Jin Man Kim: Graduate School of Medical Science and Engineering, KAIST
June-Koo Lee: Graduate School of Medical Science and Engineering, KAIST
Won Do Heo: KAIST
Joon Kim: Graduate School of Medical Science and Engineering, KAIST

Nature Communications, 2015, vol. 6, issue 1, 1-13

Abstract: Abstract Primary cilia exert a profound impact on cell signalling and cell cycle progression. Recently, actin cytoskeleton destabilization has been recognized as a dominant inducer of ciliogenesis, but the exact mechanisms regulating ciliogenesis remain poorly understood. Here we show that the actin cytoskeleton remodelling controls ciliogenesis by regulating transcriptional coactivator YAP/TAZ as well as ciliary vesicle trafficking. Cytoplasmic retention of YAP/TAZ correlates with active ciliogenesis either in spatially confined cells or in cells treated with an actin filament destabilizer. Moreover, knockdown of YAP/TAZ is sufficient to induce ciliogenesis, whereas YAP/TAZ hyperactivation suppresses serum starvation-mediated ciliogenesis. We also identify actin remodelling factors LIMK2 and TESK1 as key players in the ciliogenesis control network in which YAP/TAZ and directional vesicle trafficking are integral components. Our work provides new insights for understanding the link between actin dynamics and ciliogenesis.

Date: 2015
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DOI: 10.1038/ncomms7781

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