Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis

Xianbo Zuo, Liangdan Sun, Xianyong Yin, Jinping Gao, Yujun Sheng, Jinhua Xu, Jianzhong Zhang, Chundi He, Ying Qiu, Guangdong Wen, Hongqing Tian, Xiaodong Zheng, Shengxiu Liu, Wenjun Wang, Weiran Li, Yuyan Cheng, Longdan Liu, Yan Chang, Zaixing Wang, Zenggang Li, Longnian Li, Jianping Wu, Ling Fang, Changbing Shen, Fusheng Zhou, Bo Liang, Gang Chen, Hui Li, Yong Cui, Aie Xu, Xueqin Yang, Fei Hao, Limin Xu, Xing Fan, Yuzhen Li, Rina Wu, Xiuli Wang, Xiaoming Liu, Min Zheng, Shunpeng Song, Bihua Ji, Hong Fang, Jianbin Yu, Yongxin Sun, Yan Hui, Furen Zhang, Rongya Yang, Sen Yang and Xuejun Zhang ()
Additional contact information
Xianbo Zuo: No. 1 Hospital, Anhui Medical University
Liangdan Sun: No. 1 Hospital, Anhui Medical University
Xianyong Yin: No. 1 Hospital, Anhui Medical University
Jinping Gao: No. 1 Hospital, Anhui Medical University
Yujun Sheng: No. 1 Hospital, Anhui Medical University
Jinhua Xu: Huashan Hospital, Fudan University
Jianzhong Zhang: Peking University People’s Hospital
Chundi He: No.1 Hospital of China Medical University
Ying Qiu: Jining No. 1 People’s Hospital
Guangdong Wen: Peking University People’s Hospital
Hongqing Tian: Shandong Provincial Institute of Dermatology and Venereology
Xiaodong Zheng: No. 1 Hospital, Anhui Medical University
Shengxiu Liu: No. 1 Hospital, Anhui Medical University
Wenjun Wang: No. 1 Hospital, Anhui Medical University
Weiran Li: No. 1 Hospital, Anhui Medical University
Yuyan Cheng: No. 1 Hospital, Anhui Medical University
Longdan Liu: No. 1 Hospital, Anhui Medical University
Yan Chang: No. 1 Hospital, Anhui Medical University
Zaixing Wang: No. 1 Hospital, Anhui Medical University
Zenggang Li: No. 1 Hospital, Anhui Medical University
Longnian Li: No. 1 Hospital, Anhui Medical University
Jianping Wu: No. 1 Hospital, Anhui Medical University
Ling Fang: No. 1 Hospital, Anhui Medical University
Changbing Shen: No. 1 Hospital, Anhui Medical University
Fusheng Zhou: No. 1 Hospital, Anhui Medical University
Bo Liang: No. 1 Hospital, Anhui Medical University
Gang Chen: No. 1 Hospital, Anhui Medical University
Hui Li: No. 1 Hospital, Anhui Medical University
Yong Cui: Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
Aie Xu: The Third People's Hospital of Hangzhou
Xueqin Yang: General Hospital of PLA Air Force
Fei Hao: Southwest Hospital, Third Military Medical University
Limin Xu: Tianjin Changzheng Hospital
Xing Fan: No. 1 Hospital, Anhui Medical University
Yuzhen Li: Second Affiliated Hospital of Harbin Medical University
Rina Wu: The Affiliated Hospital of Inner Mongolia Medical College
Xiuli Wang: Shanghai Skin Diseases and STD Hospital
Xiaoming Liu: The First Affiliated Hospital of Dalian Medical University
Min Zheng: The Second Affiliated Hospital, Zhejiang University School of Medicine
Shunpeng Song: Dalian Dermatosis Hosptial
Bihua Ji: Yijishan Hospital of Wannan Medical College
Hong Fang: The First Affiliated Hospital of Zhejiang University School of Medicine
Jianbin Yu: The First Affiliated Hospital of Zhengzhou University
Yongxin Sun: Anshan Tanggangzi hosptial
Yan Hui: First Affiliated Hospital of Xinjiang Medical University
Furen Zhang: Shandong Provincial Institute of Dermatology and Venereology
Rongya Yang: General Hospital of Beijing Military Command
Sen Yang: No. 1 Hospital, Anhui Medical University
Xuejun Zhang: No. 1 Hospital, Anhui Medical University

Nature Communications, 2015, vol. 6, issue 1, 1-7

Abstract: Abstract Genome-wide association studies (GWASs) have reproducibly associated ∼40 susceptibility loci with psoriasis. However, the missing heritability is evident and the contributions of coding variants have not yet been systematically evaluated. Here, we present a large-scale whole-exome array analysis for psoriasis consisting of 42,760 individuals. We discover 16 SNPs within 15 new genes/loci associated with psoriasis, including C1orf141, ZNF683, TMC6, AIM2, IL1RL1, CASR, SON, ZFYVE16, MTHFR, CCDC129, ZNF143, AP5B1, SYNE2, IFNGR2 and 3q26.2-q27 (P

Date: 2015
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DOI: 10.1038/ncomms7793

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