Regulation of systemic energy homeostasis by serotonin in adipose tissues

Chang-Myung Oh, Jun Namkung, Younghoon Go, Ko Eun Shong, Kyuho Kim, Hyeongseok Kim, Bo-Yoon Park, Ho Won Lee, Yong Hyun Jeon, Junghan Song, Minho Shong, Vijay K. Yadav, Gerard Karsenty, Shingo Kajimura, In-Kyu Lee (), Sangkyu Park () and Hail Kim ()
Additional contact information
Chang-Myung Oh: BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology
Jun Namkung: BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology
Younghoon Go: Kyungpook National University Hospital, Kyungpook National University School of Medicine
Ko Eun Shong: BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology
Kyuho Kim: BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology
Hyeongseok Kim: BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology
Bo-Yoon Park: Kyungpook National University Hospital, Kyungpook National University School of Medicine
Ho Won Lee: Kyungpook National University Hospital, Kyungpook National University School of Medicine
Yong Hyun Jeon: Kyungpook National University Hospital, Kyungpook National University School of Medicine
Junghan Song: Seoul National University Bundang Hospital, Seoul National University College of Medicine
Minho Shong: Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine
Vijay K. Yadav: Wellcome Trust Sanger Institute
Gerard Karsenty: Columbia University Medical Center
Shingo Kajimura: Diabetes Center, University of California San Francisco
In-Kyu Lee: Kyungpook National University Hospital, Kyungpook National University School of Medicine
Sangkyu Park: BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology
Hail Kim: BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology

Nature Communications, 2015, vol. 6, issue 1, 1-12

Abstract: Abstract Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. However, accumulating evidence suggests peripheral 5-HT may affect organismal energy homeostasis. Here we show 5-HT regulates white and brown adipose tissue function. Pharmacological inhibition of 5-HT synthesis leads to inhibition of lipogenesis in epididymal white adipose tissue (WAT), induction of browning in inguinal WAT and activation of adaptive thermogenesis in brown adipose tissue (BAT). Mice with inducible Tph1 KO in adipose tissues exhibit a similar phenotype as mice in which 5-HT synthesis is inhibited pharmacologically, suggesting 5-HT has localized effects on adipose tissues. In addition, Htr3a KO mice exhibit increased energy expenditure and reduced weight gain when fed a high-fat diet. Treatment with an Htr2a antagonist reduces lipid accumulation in 3T3-L1 adipocytes. These data suggest important roles for adipocyte-derived 5-HT in controlling energy homeostasis.

Date: 2015
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DOI: 10.1038/ncomms7794

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