Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

Iben Lundgaard (), Baoman Li, Lulu Xie, Hongyi Kang, Simon Sanggaard, John D. R. Haswell, Wei Sun, Siri Goldman, Solomiya Blekot, Michael Nielsen, Takahiro Takano, Rashid Deane and Maiken Nedergaard ()
Additional contact information
Iben Lundgaard: Center for Translational Neuromedicine, University of Rochester
Baoman Li: Center for Translational Neuromedicine, University of Rochester
Lulu Xie: Center for Translational Neuromedicine, University of Rochester
Hongyi Kang: Center for Translational Neuromedicine, University of Rochester
Simon Sanggaard: Center for Translational Neuromedicine, University of Rochester
John D. R. Haswell: Center for Translational Neuromedicine, University of Rochester
Wei Sun: Center for Translational Neuromedicine, University of Rochester
Siri Goldman: Center for Translational Neuromedicine, University of Rochester
Solomiya Blekot: Center for Translational Neuromedicine, University of Rochester
Michael Nielsen: Center for Translational Neuromedicine, University of Rochester
Takahiro Takano: Center for Translational Neuromedicine, University of Rochester
Rashid Deane: Center for Translational Neuromedicine, University of Rochester
Maiken Nedergaard: Center for Translational Neuromedicine, University of Rochester

Nature Communications, 2015, vol. 6, issue 1, 1-12

Abstract: Abstract Metabolically, the brain is a highly active organ that relies almost exclusively on glucose as its energy source. According to the astrocyte-to-neuron lactate shuttle hypothesis, glucose is taken up by astrocytes and converted to lactate, which is then oxidized by neurons. Here we show, using two-photon imaging of a near-infrared 2-deoxyglucose analogue (2DG-IR), that glucose is taken up preferentially by neurons in awake behaving mice. Anaesthesia suppressed neuronal 2DG-IR uptake and sensory stimulation was associated with a sharp increase in neuronal, but not astrocytic, 2DG-IR uptake. Moreover, hexokinase, which catalyses the first enzymatic steps in glycolysis, was highly enriched in neurons compared with astrocytes, in mouse as well as in human cortex. These observations suggest that brain activity and neuronal glucose metabolism are directly linked, and identiy the neuron as the principal locus of glucose uptake as visualized by functional brain imaging.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms7807 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7807

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms7807

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().