A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses

Jianning Lu, Ceng Luo, Kiran Kumar Bali, Rou-Gang Xie, Richard E. Mains, Betty A. Eipper and Rohini Kuner ()
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Jianning Lu: Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University
Ceng Luo: Institute of Neuroscience, Fourth Military Medical University
Kiran Kumar Bali: Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University
Rou-Gang Xie: Institute of Neuroscience, Fourth Military Medical University
Richard E. Mains: University of Connecticut Health Center
Betty A. Eipper: University of Connecticut Health Center
Rohini Kuner: Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University

Nature Communications, 2015, vol. 6, issue 1, 1-10

Abstract: Abstract Synaptic plasticity is the cornerstone of processes underlying persistent nociceptive activity-induced changes in normal nociceptive sensitivity. Kalirin-7 is a multifunctional guanine-nucleotide-exchange factor (GEF) for Rho GTPases that is characterized by its localization at excitatory synapses, interactions with glutamate receptors and its ability to dynamically modulate the neuronal cytoskeleton. Here we show that spinally expressed Kalirin-7 is required for persistent nociceptive activity-dependent synaptic long-term potentiation as well as activity-dependent remodelling of synaptic spines in the spinal dorsal horn, thereby orchestrating functional and structural plasticity during the course of inflammatory pain.

Date: 2015
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DOI: 10.1038/ncomms7820

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