Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion

Monika Pruenster, Angela R. M. Kurz, Kyoung-Jin Chung, Xiao Cao-Ehlker, Stephanie Bieber, Claudia F. Nussbaum, Susanne Bierschenk, Tanja K. Eggersmann, Ina Rohwedder, Kristina Heinig, Roland Immler, Markus Moser, Uwe Koedel, Sandra Gran, Rodger P. McEver, Dietmar Vestweber, Admar Verschoor, Tomas Leanderson, Triantafyllos Chavakis, Johannes Roth, Thomas Vogl and Markus Sperandio ()
Additional contact information
Monika Pruenster: Institute of Cardiovascular Physiology and Pathophysiology, Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians Universität
Angela R. M. Kurz: Institute of Cardiovascular Physiology and Pathophysiology, Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians Universität
Kyoung-Jin Chung: Institute for Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden
Xiao Cao-Ehlker: Institute of Cardiovascular Physiology and Pathophysiology, Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians Universität
Stephanie Bieber: Institute of Cardiovascular Physiology and Pathophysiology, Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians Universität
Claudia F. Nussbaum: Institute of Cardiovascular Physiology and Pathophysiology, Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians Universität
Susanne Bierschenk: Institute of Cardiovascular Physiology and Pathophysiology, Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians Universität
Tanja K. Eggersmann: Institute of Cardiovascular Physiology and Pathophysiology, Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians Universität
Ina Rohwedder: Institute of Cardiovascular Physiology and Pathophysiology, Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians Universität
Kristina Heinig: Institute of Cardiovascular Physiology and Pathophysiology, Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians Universität
Roland Immler: Institute of Cardiovascular Physiology and Pathophysiology, Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians Universität
Markus Moser: Max Planck Institute for Biochemistry
Uwe Koedel: Ludwig-Maximilians Universität
Sandra Gran: Institute of Immunology, University of Muenster
Rodger P. McEver: Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
Dietmar Vestweber: Max Planck Institute for Biomolecular Medicine
Admar Verschoor: Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität
Tomas Leanderson: Immunology Group, University of Lund
Triantafyllos Chavakis: Institute for Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden
Johannes Roth: Institute of Immunology, University of Muenster
Thomas Vogl: Institute of Immunology, University of Muenster
Markus Sperandio: Institute of Cardiovascular Physiology and Pathophysiology, Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians Universität

Nature Communications, 2015, vol. 6, issue 1, 1-11

Abstract: Abstract Myeloid-related proteins (MRPs) 8 and 14 are cytosolic proteins secreted from myeloid cells as proinflammatory mediators. Currently, the functional role of circulating extracellular MRP8/14 is unclear. Our present study identifies extracellular MRP8/14 as an autocrine player in the leukocyte adhesion cascade. We show that E-selectin–PSGL-1 interaction during neutrophil rolling triggers Mrp8/14 secretion. Released MRP8/14 in turn activates a TLR4-mediated, Rap1-GTPase-dependent pathway of rapid β2 integrin activation in neutrophils. This extracellular activation loop reduces leukocyte rolling velocity and stimulates adhesion. Thus, we identify Mrp8/14 and TLR4 as important modulators of the leukocyte recruitment cascade during inflammation in vivo.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms7915 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7915

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms7915

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().