Three-dimensional nanoscale molecular imaging by extreme ultraviolet laser ablation mass spectrometry

Ilya Kuznetsov, Jorge Filevich, Feng Dong, Mark Woolston, Weilun Chao, Erik H. Anderson, Elliot R. Bernstein, Dean C. Crick, Jorge J. Rocca and Carmen S. Menoni ()
Additional contact information
Ilya Kuznetsov: NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
Jorge Filevich: NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
Feng Dong: NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
Mark Woolston: NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
Weilun Chao: NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
Erik H. Anderson: NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
Elliot R. Bernstein: NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
Dean C. Crick: Immunology and Pathology, Colorado State University
Jorge J. Rocca: NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
Carmen S. Menoni: NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University

Nature Communications, 2015, vol. 6, issue 1, 1-6

Abstract: Abstract Analytical probes capable of mapping molecular composition at the nanoscale are of critical importance to materials research, biology and medicine. Mass spectral imaging makes it possible to visualize the spatial organization of multiple molecular components at a sample’s surface. However, it is challenging for mass spectral imaging to map molecular composition in three dimensions (3D) with submicron resolution. Here we describe a mass spectral imaging method that exploits the high 3D localization of absorbed extreme ultraviolet laser light and its fundamentally distinct interaction with matter to determine molecular composition from a volume as small as 50 zl in a single laser shot. Molecular imaging with a lateral resolution of 75 nm and a depth resolution of 20 nm is demonstrated. These results open opportunities to visualize chemical composition and chemical changes in 3D at the nanoscale.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms7944 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7944

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms7944

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().