Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis

Zhongbin Deng (), Jingyao Mu, Michael Tseng, Binks Wattenberg, Xiaoying Zhuang, Nejat K. Egilmez, Qilong Wang, Lifeng Zhang, James Norris, Haixun Guo, Jun Yan, Bodduluri Haribabu, Donald Miller and Huang-Ge Zhang ()
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Zhongbin Deng: James Graham Brown Cancer Center, University of Louisville
Jingyao Mu: James Graham Brown Cancer Center, University of Louisville
Michael Tseng: University of Louisville
Binks Wattenberg: James Graham Brown Cancer Center, University of Louisville
Xiaoying Zhuang: James Graham Brown Cancer Center, University of Louisville
Nejat K. Egilmez: James Graham Brown Cancer Center, University of Louisville
Qilong Wang: James Graham Brown Cancer Center, University of Louisville
Lifeng Zhang: James Graham Brown Cancer Center, University of Louisville
James Norris: Medical University of South Carolina
Haixun Guo: James Graham Brown Cancer Center, University of Louisville
Jun Yan: James Graham Brown Cancer Center, University of Louisville
Bodduluri Haribabu: James Graham Brown Cancer Center, University of Louisville
Donald Miller: James Graham Brown Cancer Center, University of Louisville
Huang-Ge Zhang: James Graham Brown Cancer Center, University of Louisville

Nature Communications, 2015, vol. 6, issue 1, 1-15

Abstract: Abstract Gut-associated inflammation plays a crucial role in the progression of colon cancer. Here, we identify a novel pathogen–host interaction that promotes gut inflammation and the development of colon cancer. We find that enteropathogenic bacteria-secreted particles (ET-BSPs) stimulate intestinal epithelium to produce IDENs (intestinal mucosa-derived exosome-like nanoparticles) containing elevated levels of sphingosine-1-phosphate, CCL20 and prostaglandin E2 (PGE2). CCL20 and PGE2 are required for the recruitment and proliferation, respectively, of Th17 cells, and these processes also involve the MyD88-mediated pathway. By influencing the recruitment and proliferation of Th17 cells in the intestine, IDENs promote colon cancer. We demonstrate the biological effect of sphingosine-1-phosphate contained in IDENs on tumour growth in spontaneous and transplanted colon cancer mouse models. These findings provide deeper insights into how host–microbe relationships are mediated by particles secreted from both bacterial and host cells.

Date: 2015
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DOI: 10.1038/ncomms7956

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